References

vestnik-bio-msu

Вестник Московского университета. Серия 16. Биология

Vestnik Moskovskogo universiteta. Seriya 16. Biologiya

0137-0952

Lomonosov Moscow State University, School of Biology

10.55959/MSU0137-0952-16-78-2-8

vestnik-bio-msu-1229

Research Article

ОБЗОР

REVIEW

Нейтрофилы – атипичные антигенпрезентирующие клетки

Neutrophils are atypical antigen-presenting cells

https://orcid.org/0000-0001-5233-9338

Воробьева

Н. В.

Vorobjeva

N. V.

Воробьева Нина Викторовна – канд. биол. наук, ст. науч. сотр. кафедры иммунологии биологического факультета. Тел.: 8-495-939-46-46

119234, г. Москва, Ленинские горы, д. 1, стр. 12

Department of Immunology, Biological Faculty

1–12 Leninskie gory, Moscow, 119234

nvvorobjeva@mail.ru

Московский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation

2023

09072023

7825563

2023

Воробьева Н.В.

Vorobjeva N.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vestnik-bio-msu.elpub.ru/jour/article/view/1229

Нейтрофилы представляют собой наиболее многочисленные лейкоциты крови и являются «первой линией» защиты от патогенов в очаге воспаления, где осуществляют такие эффекторные функции, как фагоцитоз, дегрануляция, генерация активных форм кислорода и образование нейтрофильных внеклеточных ловушек. Долгое время считалось, что нейтрофилы являются короткоживущими терминально дифференцированными фагоцитами. Однако эта точка зрения изменилась после того, как было обнаружено, что нейтрофилы способны взаимодействовать с другими популяциями лейкоцитов, а также отвечать за связь между врожденным и адаптивным иммунитетом. В последние годы накопилось много данных, указывающих на способность нейтрофилов приобретать функцию антигенпрезентирующих клеток при патологических и воспалительных состояниях. Кроме того, нейтрофилы могут экспрессировать молекулы главного комплекса гистосовместимости класса II и костимулирующие молекулы при воздействии специфических цитокинов в системе in vitro и активировать Т-лимфоциты. В обзоре обобщены сведения последних лет об антигенпрезентирующей функции нейтрофилов, предполагаемых механизмах регуляции этого процесса и его значении в норме и патологии.

Neutrophils are the most abundant leukocytes in the blood and the “first line” of defense against pathogens in the inflammation foci, where they perform effector functions such as phagocytosis, degranulation, generation of reactive oxygen species, and the formation of neutrophil extracellular traps. For a long time, it was believed that neutrophils are short-lived terminally differentiated phagocytes. However, this point of view has been changed after it was found that these cells are able to interact with other populations of leukocytes, as well as mediate the relationship between innate and adaptive immunity. In recent years, a lot of data has accumulated indicating the ability of neutrophils to acquire the function of antigenpresenting cells in a number of pathological and inflammatory conditions. In addition, neutrophils can express major histocompatibility complex class II and costimulatory molecules under the influence of specific cytokines in the in vitro system and activate T lymphocytes. This review summarizes current data on the antigen-presenting function of neutrophils, the proposed mechanisms of regulation of this process and its significance in normal and pathological conditions.

нейтрофилантигенпрезентирующая клеткапрезентация антигенаглавный комплекс гистосовместимостицитокиныхемокины

neutrophilantigen-presenting cellantigen presentationmajor histocompatibility complexcytokineschemokines

Работа выполнена в рамках проекта «Молекулярные и клеточные основы иммунитета» (проект 21-1-21, номер ЦИТИС 121042600047-9) и Междисциплинарной научно-образовательной школы Московского университета «Молекулярные технологии живых систем и синтетическая биология».

The research was carried out within the framework of the project “Molecular and cellular bases of immunity” (number 21-1-21, CITIS number 121042600047-9) and Interdisciplinary Scientific and Educational School of Moscow University “Molecular Technologies of the Living Systems and Synthetic Biology.”

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The authors declare that there are no conflicts of interest present.