vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biology10.55959/MSU0137-0952-16-78-4-6vestnik-bio-msu-1240Research ArticleКРАТКОЕ СООБЩЕНИЕSHORT COMMUNICATIONВлияние различных сахарозаменителей на содержание гликогена лейкоцитов крови и состав лейкоцитарной формулы у мышей С57BL/6Effect of different sweeteners on glycogen content of blood leukocytes and differential leukocyte counts in C57BL/6 micehttps://orcid.org/0000-0003-3042-8617КижинаА. Г.KizhinaA. G.

Кижина Александра Геннадьевна – канд. биол. наук, ст. науч. сотр. лаборатории экологической физиологии животных Карельского научного центра РАН

Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences

golubewa81@yandex.ruhttps://orcid.org/0009-0002-9986-5647МащинскасМ. С.MashinskasM. S.

Мащинскас Максим Сергеевич – магистрант Института биологии, экологии и агротехнологий Петрозаводского государственного университета

lobovich17@mail.ruhttps://orcid.org/0009-0003-1124-3489ВалерьевнаП. Э.PanovaE. V.

Панова Элина Валерьевна – ведущий биолог Института биологии Карельского научного центра РАН, магистрант Института биологии, экологии и агротехнологий Петрозаводского государственного университета

Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences; Petrozavodsk State University

panova550@gmail.comhttps://orcid.org/0000-0002-2371-1740ИлюхаВ. В.IlyukhaV. V.

Илюха Владимир Викторович – канд. биол. наук, ст. преподаватель кафедры биомедицинской химии, иммунологии и лабораторной диагностики Медицинского института им. профес. А.П. Зильбера Петрозаводского государственного университета

karax911@mail.ruИнститут биологии КарНЦ РАНРоссияInstitute of Biology of the Karelian Research CentreRussian FederationПетрозаводский государственный университетРоссияPetrozavodsk State UniversityRussian FederationИнститут биологии КарНЦ РАН; Петрозаводский государственный университетРоссияInstitute of Biology of the Karelian Research Centre; Petrozavodsk State UniversityRussian Federation202327022024784273277Copyright © Кижина А.Г., Мащинскас М.С., Валерьевна П.Э., Илюха В.В., 20232023Кижина А.Г., Мащинскас М.С., Валерьевна П.Э., Илюха В.В.Kizhina A.G., Mashinskas M.S., Panova E.V., Ilyukha V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/1240

Изучали влияние экстракта листьев стевии, сахарината и цикламата в различных дозировках на содержание гликогена лейкоцитов крови у мышей C57BL/6, как необходимого субстрата для осуществления фагоцитарных реакций. Установлено увеличение содержания гликогена во всех экспериментальных группах, получавших заменители сахара в дозировке 10 мг/г массы тела. Влияние сахарозаменителей на состав лейкоцитарной формулы было выявлено только для мышей, получавших экстракт листьев стевии в дозировке 10 мг/г массы тела, и заключалось в повышении соотношения нейтрофилов и лимфоцитов (Нф/Лф). Полученные данные расширяют представления о метаболизме заменителей сахара в организме и их влиянии на физиологические системы – в частности, на гемопоэтическую и иммунную.

We studied the effect of stevia leaf extract, saccharinate and cyclamate in various dosages on the glycogen content of blood leukocytes in mice, as a necessary substrate for the realization of phagocytosis. An increase of glycogen content was found in all experimental groups which obtained sweeteners at a dosage of 10 mg/g of body weight. The effect of sweeteners on the differential leukocyte counts was found only for mice treated with stevia leaf extract at a dosage of 10 mg/g of body weight. They demonstrated increase of neutrophil-to-lymphocyte ratio. New data expand our understanding of the metabolism of sugar substitutes in the organism and their effect on physiological systems, in particular the hematopoietic and immune systems.

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The authors declare that there are no conflicts of interest present.