vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biology10.1234/XXXX-XXXX-2013-2-12-15vestnik-bio-msu-13Research ArticleФизиологияPhysiologyИССЛЕДОВАНИЕ ЗАЩИТНЫХ СВОЙСТВ БИОПОЛИМЕРОВ УГЛЕВОДНОЙ ПРИРОДЫ SHIGELLA SONNEI НА МОДЕЛЯХ ЭНДОТОКСИЧЕСКОГО ШОКАINVESTIGATION OF PROTECTIVE PROPERTIES OF SHIGELLA SONNEI CARBOHYDRATE BIOPOLYMERS UNDER EXPERIMENTAL ENDOTOXIC SHOCK MODELSМаркинаА. А.MarkinaA. A.

мл. науч. сотр. лаборатории полисахаридных вакцин ФГБУ “ГНЦ Института иммунологии” ФМБА России. Тел.: 8-909-931-61-25, 8-499-618-67-83

markinanna@mail.ruКондратьеваИ. А.KondratievaI. A.

канд. биол. наук, доц. Международного учебно-научного биотехнологического центра. Тел.: 8-926-247-74-53

kondratieva9@gmail.com201330042015021215Copyright © Маркина А.А., Кондратьева И.А., 20152015Маркина А.А., Кондратьева И.А.Markina A.A., Kondratieva I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/13

Проведено исследование толерогенных свойств нового апирогенного, низкоэндотоксичного комплексного препарата на основе биополимеров углеводной природы Shigella sonnei на D-галактозаминовой и прямой моделях эндотоксического шока. Профилактическое введение препарата защищает мышей (CBA Ѕ C57Bl/6)F1 от гибели при введении летальных доз эндотоксина E. coli О:55. На прямой модели эндотоксического шока было показано, что повышение дозы иммунизации коррелирует с увеличением выживаемости и снижением уровня ФНО-a в сыворотках крови экспериментальных животных.

Study tolerogenic properties of new non-pyrogenic low-endotoxic complex preparation composed of Shigella sonnei carbohydrate biopolymers under D-galactosamine and direct experimental endotoxic shock models. Pretreatment with complex preparation protects mice (CBA Ѕ C57Bl/6)F1 against lipopolysaccharide (E. coli O:55) — mediated death. We demonstrate correlation between increasing pre-immunization dose of complex preparation with rate of survival and reduction of TNF-a serum level under direct endotoxic shock model.

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The authors declare that there are no conflicts of interest present.