vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biology10.55959/MSU0137-0952-16-79-4-4vestnik-bio-msu-1446Research ArticleМНЕНИЕOPINIONАнтиоксиданты: полезные, вредные или нейтральные в плане влияния на старение и продолжительность жизни? Все зависит от обстоятельствAntioxidants: good, bad, or ineffective in terms of aging and lifespan? It dependshttps://orcid.org/0000-0001-7454-7023ХохловА. Н.KhokhlovA. N.

Хохлов Александр Николаевич – докт. биол. наук, зав. сектором 

119234, г. Москва, Ленинские горы, д. 1, стр. 12, Тел.: 8-495-939-15-90

1–12 Leninskie gory, Moscow, 119234 

khokhlov@mail.bio.msu.ruСектор эволюционной цитогеронтологии, биологический факультет, Московский государственный университет имени М.В. ЛомоносоваРоссияEvolutionary Cytogerontology Sector, School of Biology, Lomonosov Moscow State UniversityRussian Federation202403032025794367371Copyright © Хохлов А.Н., 20252025Хохлов А.Н.Khokhlov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/1446

Обсуждается проблема эффективности антиоксидантов в плане их влияния на «нормальное» старение и возрастные болезни. Подчеркивается, что в течение многих лет антиоксиданты считались самыми перспективными геропротекторами, способными замедлять старение, лечить возрастные болезни и увеличивать как среднюю, так и максимальную продолжительность жизни животных и человека. Однако, как отмечается, в последние годы ситуация начала кардинально меняться. Рассматриваются методологические аспекты этой проблемы – в частности, подчеркивается сложность корректного подбора эффективных концентраций таких препаратов в экспериментально-геронтологических исследованиях как на многоклеточных организмах, так и на клеточных культурах. Анализируются данные литературы, свидетельствующие о том, что во многих случаях антиоксиданты, к сожалению, могут быть даже вредны для организма, вызывая «парадоксальный» окислительный стресс и подавляя некоторые важные физиологические функции.

The problem of antioxidant efficiency in terms of their impact on “normal” aging and agerelated diseases is discussed. It is emphasized that for many years antioxidants were considered the most promising geroprotectors (anti-aging drugs) capable of slowing down aging, treating age-related diseases and increasing both the average and maximum lifespan of animals and humans. However, as noted, in recent years the situation has begun to change dramatically. The methodological aspects of this problem are considered – in particular, the complexity of the correct selection of effective concentrations of such drugs in experimental gerontological studies on both multicellular organisms and cell cultures is emphasized. The literature data is analyzed, indicating that, in many cases, antioxidants, unfortunately, can even be harmful to the body, causing “paradoxical” oxidative stress and suppressing some important physiological functions.

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The authors declare that there are no conflicts of interest present.