vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biologyvestnik-bio-msu-271Research ArticleМолекулярная биологияMolecular biologyИМПОРТ РНК В МИТОХОНДРИИ И ЕГО ПРИМЕНЕНИЕ В ГЕННОЙ ТЕРАПИИRNA IMPORT INTO MITOCHONDRIA AND ITS USE IN THE GENE THERAPYЛакунинаВалентина АлександровнаLakuninaV. A.

аспирант кафедры молекулярной биологии

carrie8@yandex.ruБалеваМария ВячеславовнаBalevaM. V.

аспирант кафедры молекулярной биологии

mary-bw@mail.ruЛевицкийСергей АлексеевичLevitskiiS. A.

канд. биол. наук, ст. науч. сотр. кафедры молекулярной биологии

krolick@yandex.ruЧичеринИван ВладимировичChicherinI. V.

аспирант кафедры молекулярной биологии

i.v.chicherin@gmail.comКрашенинниковИгорь АлександровичKrasheninnikovI. A.

канд биол. наук, проф. кафедры молекулярной биологии

igor@protrin.bio.msu.ruСамойловаЕлена ОлеговнаSamoylovaE. O.

мл. науч. сотр. кафедры молекулярной биологии

elen.samoylova@yandex.ruКаменскийПётр АндреевичKamenskiP. A.

канд. биол. наук, вед. науч. сотр. кафедры молекулярной биологии

piotr.kamenski@gmail.comбиологический факультет МГУRussian Federation201517082015033236Copyright © Лакунина В.А., Балева М.В., Левицкий С.А., Чичерин И.В., Крашенинников И.А., Самойлова Е.О., Каменский П.А., 20152015Лакунина В.А., Балева М.В., Левицкий С.А., Чичерин И.В., Крашенинников И.А., Самойлова Е.О., Каменский П.А.Lakunina V.A., Baleva M.V., Levitskii S.A., Chicherin I.V., Krasheninnikov I.A., Samoylova E.O., Kamenski P.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/271

К биологическим макромолекулам, импортирующимся в митохондрии эукариотических клеток из цитозоля, относятся белки и рибонуклеиновые кислоты. Импорт белков в митохондрии — универсальный процесс, и его механизмы описаны в достаточной степени подробно. Импорт РНК в митохондрии, напротив, показан только для некоторых групп организмов, и в каждом случае механизмы данного процесса обладают большим количеством индивидуальных особенностей. В данном обзоре рассматриваются современные данные о процессе импорта РНК в митохондрии клеток человека и обсуждается возможность использования данного процесса в генной терапии митохондриальных болезней.

Among biological macromolecules imported into the eukaryotic cells mitochondria, there are proteins and ribonucleic acids. Protein import into mitochondria is a universal process, and its mechanisms are currently well described. RNA import into mitochondria, on the contrary, is known only for several eukaryotic species, and the mechanisms of this process are largely species-specific. In this review, we summarize existing data about RNA import into mitochondria of human cells and discuss the possibilities of its implication for the gene therapy of mitochondrial diseases.

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The authors declare that there are no conflicts of interest present.