vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biologyvestnik-bio-msu-280Research ArticleВирусологияVirologyНОВЫЙ ТИП ПЛАТФОРМ ДЛЯ СБОРКИ ВАКЦИН IN VITRONEW TYPE PLATFORMS FOR IN VITRO VACCINES ASSEMBLYАтабековИ. Г.AtabekovJ. G.

докт. биол. наук, проф., зав. кафедрой Тел.: 8-495-939-55-34

atabekov@genebee.msu.ruНикитинН. А.NikitinN. A.

канд. биол. наук, зав. сектором прикладной фитовирусологии Тел.: 8-495-939-53-67

nikitin@mail.bio.msu.ruКарповаО. В.KarpovaO. V.

докт. биол. наук, проф. Тел.: 8-495-939-53-67

okar@genebee.msu.ruЦентр “Биоинженерия” РАН, г. Москва кафедра вирусологии биологического факультета МГУРоссиякафедра вирусологии биологического факультета МГУРоссия201528112015042935Copyright © Атабеков И.Г., Никитин Н.А., Карпова О.В., 20152015Атабеков И.Г., Никитин Н.А., Карпова О.В.Atabekov J.G., Nikitin N.A., Karpova O.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/280

Изучение структуры вирионов фитовирусов и вирусных белков оболочки, а также возможностей их модификации и структурной перестройки крайне важно для разработки абсолютно новых подходов для создания биотехнологической продукции, в том числе медицинского назначения. Вирусы растений обладают безусловным преимуществом при получении новых функциональных и биологически активных материалов, в частности кандидатных вакцин, так как они не патогенны для млекопитающих, в том числе для человека. В настоящем обзоре основное внимание сосредоточено на характеристике и применении в биотехнологии сферических частиц (СЧ) — платформ нового типа, полученных в результате структурной перестройки вирусов растений. СЧ не имеют структурных аналогов среди икосаэдрических вирусов и представляют собой новый тип биогенных платформ. Сборка иммуногенных комплексов СЧ-антиген in vitro открывает перспективы недорогого и быстрого получения разнообразных вакцинных препаратов.

Studying of plant virions and viral coat proteins structure, and also possibilities of their modification and structural remodeling are extremely important for development of absolutely new approaches to creation of biotechnological products, including health products. Plant viruses have clear advantage for obtaining new functional and biologically active materials, inter alia candidate vaccines, due to the fact that plant viruses are not pathogenic for mammals, including humans. The present review focuses attention on characteristic and applying in biotechnology of spherical particles (SP) — the new type platforms generated by structural remodeling of plant viruses. SPs have no structural analogs among the icosahedral viruses and represent the new type of biogenic platforms. Assembly of immunogenic complexes of SP-antigen in vitro opens perspectives of inexpensive and rapidly produced various vaccines.

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The authors declare that there are no conflicts of interest present.