vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biologyvestnik-bio-msu-498Research ArticleГеронтологияGerontologyЕСТЬ ЛИ У СТАРЕНИЯ ЦЕЛЬ?DOES AGING HAVE A PURPOSE?ХохловА. Н.KhokhlovA. N.

Сектор эволюционной цитогеронтологии, биологический факультет

Россия, 119234, г. Москва, Ленинские горы, д. 1, стр. 12

докт. биол. наук, зав. сектором эволюционной цитогеронтологии биологического факультета МГУ. Тел.: 8-495-939-15-90

Evolutionary Cytogerontology Sector, School of Biology

Leninskiye gory 1–12, Moscow, 119234, Russia

khokhlov@mail.bio.msu.ruКлебановА. А.KlebanovA. A.

Сектор эволюционной цитогеронтологии, биологический факультет

Россия, 119234, г. Москва, Ленинские горы, д. 1, стр. 12

науч. сотр. сектора эволюционной цитогеронтологии биологического факультета МГУ. Тел.: 8-495-939-15-90

Evolutionary Cytogerontology Sector, School of Biology

Leninskiye gory 1–12, Moscow, 119234, Russia

klebanov@mail.bio.msu.ruМоргуноваГ. В.MorgunovaG. V.

Сектор эволюционной цитогеронтологии, биологический факультет

Россия, 119234, г. Москва, Ленинские горы, д. 1, стр. 12

науч. сотр. сектора эволюционной цитогеронтологии биологического факультета МГУ. Тел.: 8-495-939-15-90

Evolutionary Cytogerontology Sector, School of Biology

Leninskiye gory 1–12, Moscow, 119234, Russia

morgunova@mail.bio.msu.ruМосковский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation201720102017724258261Copyright © Хохлов А.Н., Клебанов А.А., Моргунова Г.В., 20172017Хохлов А.Н., Клебанов А.А., Моргунова Г.В.Khokhlov A.N., Klebanov A.A., Morgunova G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/498

Кратко рассматриваются представления сторонников и противников запрограммированности старения о целесообразности этого явления для эволюции живых организмов. Мы полагаем, что у эволюции нет никакой “геронтологической” цели, ибо обязательное ограничение клеточной пролиферации в процессе развития многоклеточных организмов является фактором, “автоматически” запускающим старение из-за накопления в клетках различных макромолекулярных повреждений вследствие торможения или даже полного прекращения возникновения новых, неповрежденных, клеток. Это ведет к подавлению “разбавления” стохастических повреждений (наиболее важными из которых являются повреждения ДНК) на уровне всей клеточной популяции. Перечисляются также некоторые дополнительные доводы в пользу нецелесообразности старения как для вида, так и для индивида.

Ideas of proponents and opponents of the programmed aging concerning the feasibility of this phenomenon for the evolution of living organisms are shortly considered. We think that evolution has no “gerontological” purpose, because the obligate restriction of cell proliferation during the development of multicellular organisms is a factor that “automatically” launches aging due to the accumulation in the cells of various macromolecular lesions because of inhibition or even complete cessation of the appearance of new, intact cells. This leads to supression of “dilution” of stochastic damage (the most important of which are DNA lesions) at the level of the entire cellular population. Some additional arguments are also listed in favor of the inexpediency of aging for both species and indi vidual.

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The authors declare that there are no conflicts of interest present.