vestnik-bio-msuВестник Московского университета. Серия 16. БиологияVestnik Moskovskogo universiteta. Seriya 16. Biologiya0137-0952Lomonosov Moscow State University, School of Biologyvestnik-bio-msu-894Research ArticleОБЗОРREVIEWПротеолитические ферменты грибов и их ингибиторы как перспективные биоцидные средства антифунгального действияFungal proteolytic enzymes and their inhibitors as perspective biocides with antifungal actionШамрайчукИ. Л.ShamraychukI. L.

Шамрайчук Ирина Леонидовна - эксперт по технико-технологической экспертизе в лаборатории химико-биологических исследований, соискатель отдела белков растений НИИ физико-химической биологии

119992, г. Москва, Ленинские горы, 1, стр. 40

105005, г. Москва, ул. Радио, 17, корп. 6, тел.: 8-499-763-37-10

Leninskiye gory 1–40, Moscow, 119992

irashamr@yandex.ruБеляковаГ. А.BelyakovaG. A.

Белякова Галина Алексеевна - канд. биол. наук, доц. кафедры микологии и альгологии биологического факультета МГУ

119234, г. Москва, Ленинские горы, 1, стр. 12, тел.: 8-495-939-27-49

Leninskiye gory 1–12, Moscow, 119234

adm-odo@yandex.ruЕреминаИ. М.EreminaI. M.

Еремина Ирина Михайловна - зав. лабораторией химико-биологических исследований

105005, г. Москва, ул. Радио, 17, корп. 6, тел.: 8-499-763-37-10

ul. Radio 17–6, Moscow, 105005

i.m.eremina@grabar.ruКураковА. В.KurakovA. V.

Кураков Александр Васильевич - докт. биол. наук, зав. кафедрой микологии и альгологии биологического факультета МГУ

119234, г. Москва, Ленинские горы, тел.: 8-495-939-39-70

Leninskiye gory 1–12, Moscow, 119234

kurakov57@mail.ruБелозерскийМ. А.BelozerskyM. A.

Белозерский Михаил Андреевич - докт. биол. наук, зав. отделом белков растений НИИ физико-химической биологии имени А.Н. Белозерского МГУ

119992, г. Москва, Ленинские горы, 1, стр. 40, тел.: 8-495-939-55-51

Leninskiye gory 1–40, Moscow, 119992

mbeloz@belozersky.msu.ruДунаевскийЯ. Е.DunaevskyY. E.

Дунаевский Яков Ефимович - докт. биол. наук, гл. науч. сотр. НИИ физико-химической биологии имени А.Н. Белозерского МГУ

119992, г. Москва, Ленинские горы, 1, стр. 40, тел.: 8-495-939-55-51

Leninskiye gory 1–40, Moscow, 119992

dun@belozersky.msu.ruНаучно-исследовательский институт физико-химической биологии имени А.Н. Белозерского; Московский государственный университет имени М.В. Ломоносова; Всероссийский художественный научно-реставрационный центр имени академика И.Э. ГрабаряРоссияDepartment of Plant Proteins, A.N. Belozersky Research Institute of Physico-Chemical Biology; Lomonosov Moscow State UniversityRussian FederationМосковский государственный университет имени М.В. ЛомоносоваРоссияDepartment of Mycology and Algology, Faculty of Biology, Lomonosov Moscow State UniversityRussian FederationВсероссийский художественный научно-реставрационный центр имени академика И.Э. ГрабаряРоссияLaboratory of Chemico-Biological Researches, The Grabar Art Conservation CenterRussian FederationНаучно-исследовательский институт физико-химической биологии имени А.Н. Белозерского; Московский государственный университет имени М.В. ЛомоносоваРоссияDepartment of Plant Proteins, A.N. Belozersky Research Institute of Physico-Chemical Biology; Lomonosov Moscow State UniversityRussian Federation202029072020753123130Copyright © Шамрайчук И.Л., Белякова Г.А., Еремина И.М., Кураков А.В., Белозерский М.А., Дунаевский Я.Е., 20202020Шамрайчук И.Л., Белякова Г.А., Еремина И.М., Кураков А.В., Белозерский М.А., Дунаевский Я.Е.Shamraychuk I.L., Belyakova G.A., Eremina I.M., Kurakov A.V., Belozersky M.A., Dunaevsky Y.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnik-bio-msu.elpub.ru/jour/article/view/894

Обзор посвящен выявлению групп пептидаз, вовлеченных в процессы роста грибов, а также ингибиторов таких пептидаз. Рассмотрены имеющиеся данные по разнообразию, значимости, представленности и особенностям протеолитических ферментов представителей родов Aspergillus, Penicillium, Trichoderma и Alternaria. На основе анализа данных сделан вывод, что сериновые, металло- и глутаминовые пептидазы необходимы для роста грибов. Поэтому эти ферменты рассматриваются как перспективные мишени ингибиторов пептидаз, что может служить обоснованием поиска таких ингибиторов и разработки на их основе новых биоцидных средств для защиты объектов искусства от биодеструкторов.

The review is dedicated to search for peptidase groups responsible for fungal growth and for inhibitors of these peptidases. Available data on diversity, significance, distribution and peculiarities of proteolytic enzymes of fungi of the genera Aspergillus, Penicillium, Trichoderma and Alternaria are discussed. According to analysis of the data we concluded that serine, metalloand glutamic peptidases are necessary for fungal growth. Thus, these enzymes are considered as perspective targets for inhibitors that may serve as the reason to search for such inhibitors and development of novel biocides on their basis that protect works of art against biodestruction.

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The authors declare that there are no conflicts of interest present.