The antioxidant system activity during normal pregnancy and pregnancy following by hypoxic stress

The antioxidant system activity during normal pregnancy and pregnancy following by hypoxic stress

Pregnancy in mammals is characterized by an increase in basal oxygen consumption, as it develops there is an increase in oxidative stress while in pregnancy complicated by hypoxic stress the oxidative damage enhances. The oxidative stress during prenatal development seems to be one of the key factors in the pathogenesis of most pregnancy disorders, including preterm birth and preeclampsia. The growing demand for oxygen increases either the production of reactive oxygen species or the synthesis of antioxidant defense components. To assess the antioxidant defense activity in rats, the content of non-protein thiols in the blood and liver homogenate, catalase activity in liver homogenate, superoxide dismutase activity in blood plasma and liver homogenate, total antioxidant activity in blood plasma, and the intensity of lipid peroxidation in blood plasma and liver homogenate were determined. According to data obtained a decrease in antioxidant defense activity in blood plasma and liver of females is shown in the prenatal period of normal pregnancy and, particularly, in the same period of pregnancy complicated by hypoxic stress. It can be assumed that changes in blood antioxidant defense parameters reflect changes not only in mother’s body, but also in placenta, providing potential danger to the developing fetus.

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