Рrenatal hypoxia of the period of early organogenesis influence on heart rate variability in rat pups during the first month of life
https://doi.org/10.55959/MSU0137-0952-16-79-2-8
Abstract
Recently, there has been increasing evidence in favor of prenatal programming influence on the development of many diseases in adults, including cardiovascular pathologies. However, the mechanisms underlying the programming effect of developing cardiovascular dysfunction remain unclear, which prevents timely diagnosis and identification of potential clinical therapy. The aim of this study was to evaluate the effects of acute hypoxia during early organogenesis on heart rhythm formation and its regulation in early postnatal development in rats. It was shown that acute hypoxia suffered by rat pups on the 10th day of intrauterine development did not change the overall dynamics of heart rhythm formation in the first month of postnatal period. However, the experimental animals showed lower heart rate compared to control in the first weeks of life in addition to higher values of rhythm variability and the RMSSD index (root mean square of successive differences in R-R intervals) indicating an expressed tone of parasympathetic division of the ANS. Moreover in the first week of life the basic heart rate following pharmacological blockade of sympathetic and parasympathetic cardiotropic nervous influences in rats suffered from prenatal hypoxia turned out to be 15% higher than in control animals, supposing prenatal hypoxia influence on heart rhythm formation due to intracardiac mechanisms.
Keywords
prenatal hypoxia,
heart rate variability,
autonomic nervous system,
intrauterine programming,
early postnatal period
Supporting agencies: This study was performed under the state assignment of Moscow State University, project number №121032300071-8.
About the Authors
A. V. Graf
Lomonosov Moscow State University;
I.V. Kurchatov Phystech School of Nature-like, Plasma and Nuclear Technologies
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow;
Maximova St. 4, 123098, Moscow
A. S. Maklakova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow
M. V. Maslova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow
Ya. V. Krushinskaya
Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow
A. A. Guseva
Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow
N. A. Sokolova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Faculty of Biology, Leninskie gory 1–12, 119234 Moscow
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Review
For citations:
Graf A.V., Maklakova A.S., Maslova M.V., Krushinskaya Ya.V., Guseva A.A., Sokolova N.A. Рrenatal hypoxia of the period of early organogenesis influence on heart rate variability in rat pups during the first month of life. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2024;79(2):151-159. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-79-2-8
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