Preview

Vestnik Moskovskogo universiteta. Seriya 16. Biologiya

Advanced search

Cytokines – regulators of immunity

https://doi.org/10.55959/MSU0137-0952-16-79-2S-3

Abstract

This short review focuses on cytokines, molecular mediators of immunity and many other physiological functions of the body. Research on cytokines revealed new principles of cell-tocell communications and new paradigms in intracellular signal transduction. A few recombinant cytokines and, paradoxically, some cytokine inhibitors found practical use in medicine.

About the Author

S. A. Nedospasov
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Sirius University of Science and Technology
Russian Federation

st. Ostrovityanova, 1, Moscow, 119997;

“Sirius” Federal Territory, Olympic Ave. 1, Krasnodar region, 354340



References

1. Иммунология по Ярилину: учебник, 2-е изд., испр. и доп. Под ред. С.А. Недоспасова и Д.В. Купраша. Москва: ГЭОТАР-Медиа; 2021. 808 с.

2. Dinarello C.A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol. Rev. 2018;281(1):8–27.

3. Locksley R.M, Killeen N, Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104(4):487–501.

4. de Weerd N.A, Nguyen T. The interferons and their receptors—distribution and regulation. Immunol. Cell Biol. 2012;90(5):483–491.

5. Leonard W.J, Lin J.X, O’Shea J.J. The γc family of cytokines: Basic biology to therapeutic ramifications. Immunity. 2019;50(4):832–850.

6. Hercus T.R., Kan W.L.T, Broughton S.E., et al. Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harb. Perspect. Biol. 2018;10(6):a028514.

7. Wang X, Lupardus P, Laporte S.L., Garcia K.C. Structural biology of shared cytokine receptors. Annu. Rev. Immunol. 2009;27:29–60.

8. Vignali D.A., Kuchroo V.K. IL-12 family cytokines: immunological playmakers. Nat. Immunol. 2012;13(8):722–728.

9. Sabbah D.A, Hajjo R, Sweidan K. Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors. Curr. Top. Med. Chem. 2020;20(10):815–834.

10. Heldin C.H, Moustakas A. Signaling receptors for TGF-β family members. Cold Spring Harb. Perspect. Biol. 2016;8(8):a022053.

11. Allen S.J, Crown S.E, Handel T.M. Chemokine: receptor structure, interactions, and antagonism. Annu. Rev. Immunol. 2007;25:787–820.

12. Monaco C., Nanchahal J., Taylor P., Feldmann M. Anti-TNF therapy: past, present and future. Int. Immunol. 2015;27(1):55–62.


Review

For citations:


Nedospasov S.A. Cytokines – regulators of immunity. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2024;79(2S):16-21. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-79-2S-3

Views: 164


ISSN 0137-0952 (Print)