Multiple sclerosis. Some features of pathology and prospects for therapy. Part 2
https://doi.org/10.55959/MSU0137-0952-16-79-4-1
Abstract
Multiple sclerosis (MS) is one of the most common neurological diseases and the number of affected people is constantly growing worldwide. Untreated MS leads to disability of the most capable part of the young population, and in recent years it has been diagnosed increasingly in elderly patients as well. The second part of our review is devoted to the prospects of MS therapies currently under development. Mitochondria and the use of mitochodria-targeted antioxidants, neutrophils, as well as immune cells affected by pathology and other differentiated cells, which can be reprogrammed and replaced by healthy cells using stem cells, are considered as targets in MS treatment. Helminth therapy, accompanied by a shift in the composition of the microbiota of MS patients and the release of antioxidants in the tissues of the examined humans and model animals, may lead to immunomodulation and reduction of oxidative stress, providing significant attenuation of the disease. Approaches to the treatment of elderly MS patients are discussed.
Keywords
multiple sclerosis,
oxidative stress,
reactive oxygen species,
neutrophils,
mitochondria–targeted antioxidants,
stem cells,
helminth therapy,
aging
Supporting agencies: This research was performed under the state assignment of Moscow State University, project numbers 119121690043-3, 1243020800089-2, 121042600047-9.
About the Authors
E. K. Fetisova
Belozersky Institute of Physico–Chemical Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–40 Leninskie Gory, Moscow, 1119991
N. V. Vorobjeva
Biology Faculty, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–12 Leninskie Gory, Moscow, 119234
M. S. Muntyan
Belozersky Institute of Physico–Chemical Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–40 Leninskie Gory, Moscow, 1119991
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Review
For citations:
Fetisova E.K., Vorobjeva N.V., Muntyan M.S. Multiple sclerosis. Some features of pathology and prospects for therapy. Part 2. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2024;79(4):269-279. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-79-4-1
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