ANALYSIS OF THE DEGENERATE MOTIVES IN PROMOTERS OF miRNA GENES EXPRESSED IN DIFFERENT TISSUES OF MAMMALIANS
https://doi.org/10.1234/XXXX-XXXX-2010-4-73-75
Abstract
The computer approach is developed to reveal the significant oligonucleotide motives in regulatory regions of eukaryotic genes. The regulatory signals, specific for promoter regions of miRNA genes, which are expressed in different tissues of mammalians, are obtained and classified.
About the Authors
O. V. Vishnevsky
Институт цитологии и генетики СО РАН, г. Новосибирск; кафедра информационной биологии факультета естественных наук Новосибирского государственного университета, г. Новосибирск
Russian Federation
Russian Federation
K. V. Гунбин
Gunbin
Russian Federation
Russian Federation
A. V. Bocharnikov
кафедра информационной биологии факультета естественных наук Новосибирского государственного университета, г. Новосибирск
Russian Federation
Russian Federation
E. V. Berezikov
Институт цитологии и генетики СО РАН, г. Новосибирск; Hubrecht Institute, RNAAS, Utrecht, Netherlands
Russian Federation
Russian Federation
References
1. John B., Enright A.J., Aravin A., Tuschl T., Sander C., Marks D.S. Human microRNA targets // PLoS Biol. 2004. Vol. 2. N 11. P. 363.
2. Cai X., Hagedorn C.H., Cullen B.R. Human micro- RNAs are processed from capped, polyadenylated transcripts hat can also function as mRNAs // RNA. 2004. Vol. 10. N 12. P. 1957—1966.
3. Chen J.F., Mandel E.M., Thomson J.M., Wu Q., Cal- lis T.E., Hammond S.M., Conlon F.L., Wang D.Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation // Nature Genet. 2006. Vol. 38. N 2. P. 228—233.
4. Houbaviy H.B, Dennis L, Jaenisch R., Sharp P.A. Characterization of a highly variable eutherian microRNA gene // RNA. 2005. Vol. 11. N 8. P. 1245—1257.
5. Kawaji H, Severin J., Lizio M, Waterhouse A., Ka- tayama S., Irvine K.M., Hume D.A., Forrest A.R., Suzuki H., Carninci P., Hayashizaki Y., Daub C.O. The FANTOM web resource: from mammalian transcriptional landscape to its dy¬namic regulation // Genome Biol. 2009. Vol. 10. N 4. P. 40.
6. Vishnevsky O.V., Kolchanov N.A. ARGO: a web system for the detection of degenerate motifs and large-scale recognition of eukaryotic promoters // Nucleic Acids Res. 2005. Vol. 33. Web Server issue. P. 417—422.
7. Matys V., Kel-Margoulis O., Fricke E., Liebich I., Land S., Barre-Dirrie A., Reuter I., Chekmenev D., Krull M., Hornischer K., Voss N., Stegmaier P., Lewicki-Potapov B., Sa- xel H, Kel A., Wingender E. TRANSFAC(r) and its module TRANSCompel(r): transcriptional gene regulation in eukaryotes // Nucleic Acids Res. 2006. Vol. 34. Database issue. P. 108—110.
8. Kolchanov N.A., Ignatieva E.V., Ananko E.A., Podkolodnaya O.A., Stepanenko I.L., Merkulova T.I., Pozdnya- kov M.A., Podkolodny N.L., Naumochkin A.N., Romashchen- ko A.G. Transcription Regulatory Regions Database (TRRD): its status in 2002 // Nucleic Acids Res. 2002. Vol. 30. N 1. P. 312—317.
Review
For citations:
Vishnevsky O.V., K.V., Bocharnikov A.V., Berezikov E.V. ANALYSIS OF THE DEGENERATE MOTIVES IN PROMOTERS OF miRNA GENES EXPRESSED IN DIFFERENT TISSUES OF MAMMALIANS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2010;(4):73-75. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2010-4-73-75
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