EXPERIMENTAL MODEL OF AUTISTIC DISORDER — VALPROATE INDUCED FETAL SYNDROME
Abstract
High doses of valproic acid repress histone deacetylases and modify functioning of many genes. After its prenatal injection in offspring of laboratory animals the fetal valproate syndrome occurs considered as a model of autism spectrum disorders. Our review describes features of brain condition and activity during fetal valproate syndrome at different levels, from molecular and cellular to behavioral. Special attention is paid to the social interactions, the most relevant manifestations of autistic disorder. Both literature analysis and results of the authors‘ research are presented.
About the Authors
A. V. Malyshev
биологическоий факультет МГУ
Russian Federation
Russian Federation
K. R. Abbasova
биологический факультет МГУ
Russian Federation
Russian Federation
O. A. Averina
ООО “НИИ Митоинженерии МГУ”
Russian Federation
Russian Federation
L. N. Solovieva
биологический факультет МГУ
Russian Federation
Russian Federation
V. R. Gedzun
биологический факультет МГУ
Russian Federation
Russian Federation
M. V. Gulyaev
Учебно-научный межфакультетский и междисциплинарный центр магнитной томографии и спектроскопии (ЦМТС) МГУ
Russian Federation
Russian Federation
V. A. Dubynin
биологический факультет МГУ
Russian Federation
Russian Federation
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Review
For citations:
Malyshev A.V., Abbasova K.R., Averina O.A., Solovieva L.N., Gedzun V.R., Gulyaev M.V., Dubynin V.A. EXPERIMENTAL MODEL OF AUTISTIC DISORDER — VALPROATE INDUCED FETAL SYNDROME. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(3):8-12. (In Russ.)
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