ORGANIZATION OF FUNCTIONAL PROCESSES IN THE CELL NUCLEUS: THE ORDER EMERGING OUT OF DISORDER
Abstract
This review analyses the current views on the spatial organization of the eukaryotic genome and functional compartmentalization of the eukaryotic cell nucleus. The idea that folded genome constitutes a platform for the compartmentalization of the cell nucleus is considered and justified. Different mechanisms of mutual positioning of remote genomic elements and mechanisms directing assembly of functional compartments within the cell nucleus are discussed. In particular, the role of the depletion attraction force originating under conditions of macromolecular crowding is highlighted. In the last section of the review the model is discussed that postulate a crucial role of stochastic processes in establishing of the socalled functional architecture of the eukaryotic genome as well as in assembly of functional nuclear compartments.
About the Authors
S. V. Razin
биологический факультет МГУ;
Институт биологии гена РАН
Russian Federation
Russian Federation
A. A. Gavrilov
Институт биологии гена РАН
Russian Federation
Russian Federation
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Razin S.V., Gavrilov A.A. ORGANIZATION OF FUNCTIONAL PROCESSES IN THE CELL NUCLEUS: THE ORDER EMERGING OUT OF DISORDER. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(3):13-20. (In Russ.)
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