EPIGENETIC AND ENDOCRINE DETERMINANTS OF DIFFERENCES IN LIFESPAN BETWEEN CASTES OF SOCIAL INSECTS
Abstract
Social insects are promising model organisms in the study of the mechanisms determining longevity. They have the caste system in which the same genome may produce phenotypes significantly differing in longevity. In honeybee, caste differentiation depends on the duration of supply by specific nutrient mixture (royal jelly) on the larval stage. Longer feeding by the royal jelly leads to the formation of the queen epigenome which differs from the epigenome of worker bee. Such epigenetic differences, in turn, induce endocrine changes manifested in increased synthesis of juvenile hormone and activation of TOR signaling pathway, as well as in the modulation of insulin/IGF-1 pathway in queen-destined larvae. In adults, these processes influence the synthesis of vitellogenin (egg yolk precursor affecting many aspects of insect ontogenesis). Epigenetic and endocrine mechanisms that underlie differences in longevity among social insect castes are discussed.
About the Author
A. M. Vaiserman
ГУ “Институт геронтологии им. Д.Ф. Чеботарева” НАМН Украины, Киев, Украина
Russian Federation
Russian Federation
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Vaiserman A.M. EPIGENETIC AND ENDOCRINE DETERMINANTS OF DIFFERENCES IN LIFESPAN BETWEEN CASTES OF SOCIAL INSECTS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(4):8-14. (In Russ.)
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