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БИОЛОГИЧЕСКАЯ РОЛЬ 8-ОКСО-2’-ДЕЗОКСИГУАНОЗИНА
Аннотация
В обзоре приведены имеющиеся на настоящий момент данные о биологической роли 8-оксо-2’-дезоксигуанозина. Это соединение довольно давно и успешно используется в качестве биомаркера окислительного стресса и сопряженных с ним заболеваний. Однако в последние годы появляется все больше публикаций, сообщающих о том, что биологическое значение 8-oxo-dG заключается не только в его мутагенной роли, но и в участии в регуляции экспрессии генов, некоторых процессах репарации ДНК, контроле воспалительных и аутоиммунных реакций, запуске антиоксидантных систем. Возможно, существует перспектива применения 8-oxo-dG в качестве лекарственного препарата.
Об авторах
Н. В. МармийРоссия
аспирант Тел.: 8-495-939-35-28
Д. С. Есипов
Россия
канд. хим. наук, доцент Тел.: 8-495-939-35-28
Список литературы
1. Kuchino Y., Mori F., Kasai H., Inoue H., Iwai S., Miura K., Ohtsuka E., Nishimura S. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues // Nature. 1987. Vol. 327. N 6117. P. 77–79.
2. Johansen M.E., Muller J.G., Xu X., Burrows C.J. Oxidatively induced DNA-protein cross-linking between singlestranded binding protein and oligodeoxynucleotides containing 8-oxo-7,8-dihydro-2’-deoxyguanosine // Biochemistry. 2005. Vol. 44. N 15. P. 5660–5671.
3. Kawanishi S., Oikawa S. Mechanism of telomere shortening by oxidative stress // Ann. N.Y. Acad. Sci. 2004. Vol. 1019. P. 278–284.
4. Preston T.J., Henderson J.T., McCallum G.P., Wells P.G. Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2’-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs // Mol. Cancer. Ther. 2009. Vol. 8. N 7. P. 2015–2026.
5. Völker J., Plum G.E., Klump H.H., Breslauer K.J. Energetic coupling between clustered lesions modulated by intervening triplet repeat bulge loops: allosteric implications for DNA repair and triplet repeat expansion // Biopolymers. 2010. Vol. 93. N 4. P. 355–369.
6. Morero N.R., Argaraña C.E. Pseudomonas aeruginosa deficient in 8-oxodeoxyguanine repair system shows a high frequency of resistance to ciprofloxacin // FEMS Microbiol. Lett. 2009. Vol. 290. N 2. P. 217–226.
7. Garrido P., Mejia E., Garcia-Diaz M., Blanco L., Picher A.J. The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation // Nucleic Acids Res. 2014. Vol. 42. N 1. P. 534–543.
8. Delaney S., Jarem D.A., Volle C.B., Yennie C.J. Chemical and biological consequences of oxidatively damaged guanine in DNA // Free Radic. Res. 2012. Vol. 46. N 4. P. 420–441.
9. Dizdaroglu M. Oxidative damage to DNA in mammalian chromatin // Mutat. Res. 1992. Vol. 275. N 3–6. P. 331–342.
10. Svoboda P., Harms-Ringdahl M. Influence of chromatin structure and radical scavengers on yields of radiationinduced 8-oxo-dG and DNA strand breaks in cellular model systems // Radiat. Res. 2005. Vol. 164. N 3. P. 303–311.
11. Fleming A.M., Muller J.G., Dlouhy A.C., Burrows C.J. Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2’-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing // J. Am. Chem. Soc. 2012. Vol. 134. N 36. P. 15091–15102.
12. Michaels M.L., Cruz C., Grollman A.P., Miller J.H. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged from of guanine in DNA // Proc Natl. Acad. Sci. USA. 1992. Vol. 89. N 15. P. 7022–7025.
13. Michaels M.L., Tchou J., Grollman А.P., Miller J.H. A repair system for 8-oxo-7,8-dihydrodeoxyguanine // Biochemistry. 1992. Vol. 31. N 45. P. 10964–10968.
14. Livingston A.L., O’Shea V.L., Kim T., Kool E.T., David S.S. Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY // Nat. Chem. Biol. 2008. Vol. 4. N 1. P. 51–58.
15. Nguyen K.V., Burrows C.J. A prebiotic role for 8-oxoguanosine as a flavin mimic in pyrimidine dimer photorepair // J. Am. Chem. Soc. 2011. Vol. 133. P. 14586–14589.
16. Perillo B., Ombra M.N., Bertoni A., Cuozzo C., Sacchetti S., Sasso A., Chiariotti L., Malorni A., Abbondanza C., Avvedimento E.V. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression // Science. 2008. Vol. 319. N 5860. P. 202–206.
17. Stebbeds W.J., Lunec J., Larcombe L.D. An in silico study of the differential effect of oxidation on two biologically relevant G-quadruplexes: possible implications in oncogene expression // PLoS One. 2012. Vol. 7. N 8. e43735.
18. Ma H., Zheng L., Li Y., Pan S., Hu J., Yu Z., Zhang G., Sheng G., Fu J. Triclosan reduces the levels of global DNA methylation in HepG2 cells // Chemosphere. 2013. Vol. 90. N 3. P. 1023–1029.
19. Bagan J., Sáez G.T., Tormos M.C., Gavalda-Esteve C., Bagan L., Leopoldo-Rodado M., Calvo J., Camps C. Oxidative stress in bisphosphonate-related osteonecrosis of the jaws // J. Oral. Pathol. Med. 2014. Vol. 43. N 5. P. 371–377.
20. Burlaka A., Tsybulin O., Sidorik E., Lukin S., Polishuk V., Tsehmistrenko S., Yakymenko I. Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation // Exp. Oncol. 2013. Vol. 35. N 3. P. 219–225.
21. Unnikrishnan A., Prychitko T.M., Patel H.V., Chowdhury M.E., Pilling A.B., Ventrella-Lucente L.F., Papakonstantinou E.V., Cabelof D.C., Heydari A.R. Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress // Free Radic. Biol. Med. 2011. Vol. 50. N 2. P. 270–280.
22. Kim H.S., Ye S.K., Cho I.H., Jung J.E., Kim D.H., Choi S., Kim Y.S., Park C.G., Kim T.Y., Lee J.W., Chung M.H. 8-Hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia // Free Radic. Biol. Med. 2006. Vol. 41. N 9. P. 1392–1403.
23. Huh J.Y., Son D.J., Lee Y., Lee J., Kim B., Lee H.M., Jo H., Choi S., Ha H., Chung M.H. 8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation // Free Radic. Biol. Med. 2012. Vol. 53. N 1. P. 109–121.
24. Kim D.Y., Hong G.U., Ro J.Y. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L // J. Neuroinflammation. 2011. Vol. 8. N 25. P. 1–16.
25. Kim D.H., Cho I.H., Kim H.S., Jung J.E., Kim J.E., Lee K.H., Park T., Yang Y.M., Seong S.Y., Ye S.K., Chung M.H. Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression // Exp. Mol. Med. 2006. Vol. 38. N 4. P. 417–427.
26. Ock C.Y., Kim E.H., Choi D.J., Lee H.J., Hahm K.B., Chung M.H. 8-Hydroxydeoxyguanosine: not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases // World J. Gastroenterol. 2012. Vol. 18. N 4. P. 302–308.
27. Hong G.U., Kim N.G., Jeoung D., Ro J.Y. Anti-CD40 Ab- or 8-oxo-dG-enhanced Treg cells reduce development of experimental autoimmune encephalomyelitis via downregulating migration and activation of mast cells // J. Neuroimmunol. 2013. Vol. 260. N 1. P. 60–73.
28. Ko S.H., Lee J.K., Lee H.J., Ye S.K., Kim H.S., Chung M.H. 8-Oxo-2’-deoxyguanosine ameliorates features of metabolic syndrome in obese mice // Biochem. Biophys. Res. Commun. 2014. Vol. 443. N 2. P. 610–616.
29. Kim J.S., Kim D.Y., Lee J.K., Ro J.Y., Chung M.H. 8-Oxo-2’-deoxyguanosine suppresses allergy-induced lung tissue remodeling in mice // Eur. J. Pharmacol. 2011. Vol. 651. N 1–3. P. 218–226.
30. Hong G.U., Kim N.G., Ro J.Y. Expression of airway remodeling proteins in mast cell activated by TGF-β released in OVA-induced allergic responses and their inhibition by low-dose irradiation or 8-oxo-dG // Radiat. Res. 2014. Vol. 181. N 4. P. 425–438.
31. Choi S., Choi H.H., Lee S.H., Ko S.H., You H.J., Ye S.K., Chung M.H. Anti-inflammatory effects of 8-hydroxy-2’- deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice // Free Radic. Biol. Med. 2007. Vol. 43. N 12. P. 1594–1603.
32. Lee J.K., Ko S.H., Ye S.K., Chung M.H. 8-Oxo-2’-deoxyguanosine ameliorates UVB-induced skin damage in hairless mice by scavenging reactive oxygen species and inhibiting MMP expression // J. Dermatol. Sci. 2013. Vol. 70. N 1. P. 49–57.
Дополнительные файлы
Для цитирования: Мармий Н.В., Есипов Д.С. БИОЛОГИЧЕСКАЯ РОЛЬ 8-ОКСО-2’-ДЕЗОКСИГУАНОЗИНА. Вестник Московского университета. Серия 16. Биология. 2015;(4):19-23.
For citation: Marmiy N.V., Esipov D.S. BIOLOGICAL ROLE OF 8-OXO-2’-DEOXYGUANOSINE. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(4):19-23. (In Russ.)
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