БИОЛОГИЧЕСКАЯ РОЛЬ 8-ОКСО-2’-ДЕЗОКСИГУАНОЗИНА
Аннотация
В обзоре приведены имеющиеся на настоящий момент данные о биологической роли 8-оксо-2’-дезоксигуанозина. Это соединение довольно давно и успешно используется в качестве биомаркера окислительного стресса и сопряженных с ним заболеваний. Однако в последние годы появляется все больше публикаций, сообщающих о том, что биологическое значение 8-oxo-dG заключается не только в его мутагенной роли, но и в участии в регуляции экспрессии генов, некоторых процессах репарации ДНК, контроле воспалительных и аутоиммунных реакций, запуске антиоксидантных систем. Возможно, существует перспектива применения 8-oxo-dG в качестве лекарственного препарата.
Об авторах
Н. В. Мармий
кафедры биоорганической химии биологического факультета МГУ
Россия
Россия
аспирант Тел.: 8-495-939-35-28
Д. С. Есипов
кафедры биоорганической химии биологического факультета МГУ
Россия
Россия
канд. хим. наук, доцент Тел.: 8-495-939-35-28
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Для цитирования:
Мармий Н.В., Есипов Д.С. БИОЛОГИЧЕСКАЯ РОЛЬ 8-ОКСО-2’-ДЕЗОКСИГУАНОЗИНА. Вестник Московского университета. Серия 16. Биология. 2015;(4):19-23.
For citation:
Marmiy N.V., Esipov D.S. BIOLOGICAL ROLE OF 8-OXO-2’-DEOXYGUANOSINE. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(4):19-23. (In Russ.)
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