BIOLOGICAL ROLE OF 8-OXO-2’-DEOXYGUANOSINE
Abstract
The review presents currently available data on the biological role of 8-oxo-2’-deoxyguanosine. This compound has been successfully and for a long time used as a biomarker of oxidative stress and diseases associated with it. However, in recent years an increasing number of publications has appeared reporting that 8-oxo-dG is not simply a byproduct of oxidation processes, but is of great biological importance. It is assumed that it is involved in the regulation of gene expression, in some processes of DNA repair, in the control of inflammatory and autoimmune reactions, and in the activation of antioxidant systems. Probably there is a prospect of applying 8-oxo-2’-deoxyguanosine as a drug.
About the Authors
N. V. Marmiy
кафедры биоорганической химии биологического факультета МГУ
Russian Federation
Russian Federation
D. S. Esipov
кафедры биоорганической химии биологического факультета МГУ
Russian Federation
Russian Federation
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Review
For citations:
Marmiy N.V., Esipov D.S. BIOLOGICAL ROLE OF 8-OXO-2’-DEOXYGUANOSINE. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(4):19-23. (In Russ.)
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