DISTRIBUTION OF IONS AND ELECTROSTATIC POTENTIAL IN NUCLEOSOMES AS STUDIED WITH MOLECULAR DYNAMICS
Abstract
The principles of nucleosome organization and formation were studied using molecular modeling approach. Nucleosomes are compact protein–DNA complexes that plays the key role in DNA compactization and regulation of gene transcription and expression. Nucleosome assembly and operation strongly depends on the ionic environment and electrical characteristics of the medium. The distribution of monovalent ions in the system was determined. The preferred locations of the ions were
identified. The distribution of electrostatic potential around nucleosome was investigated using a new method for averaging the distribution around macromolecule drifting in the volume of the computational cell.
About the Authors
G. A. Armeev
кафедра биоинженерии биологического факультета МГУ
Russian Federation
Russian Federation
K. V. Shaitan
кафедра биоинженерии биологического факультета МГУ
Russian Federation
Russian Federation
A. K. Shaytan
кафедра биоинженерии биологического факультета МГУ
Russian Federation
Russian Federation
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Review
For citations:
Armeev G.A., Shaitan K.V., Shaytan A.K. DISTRIBUTION OF IONS AND ELECTROSTATIC POTENTIAL IN NUCLEOSOMES AS STUDIED WITH MOLECULAR DYNAMICS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2015;(4):24-28. (In Russ.)
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