WHICH AGING IN YEAST IS “TRUE”?
Abstract
Two model systems — “replicative aging” and “chronological aging” (CA), used for gerontological research on the yeast Saccharomyces cerevisiae are compared. In the first case the number of daughter cells generated by an individual mother cell before cell propagation irreversibly stops is analyzed. This makes the model very similar to the well-known Hayflick model. In case of CA the survival of yeast cell population in the stationary phase of growth is studied. It is noted that the second model is pretty similar to the “stationary phase aging” model used in the author’s laboratory for cytogerontological studies on animal and human cells. It is considered that the conception of cell proliferation restriction as the main reason of age-related accumulation in the cells of multicellular organisms of macromolecular defects (mainly — DNA damage) leading to deterioration of tissue and organ functioning and, as a result, to the increase of death probability allows to explain how the aging process proceeds in almost any living organisms. Apparently, in all cases the process is initiated by appearance of slow propagating (or not propagating at all) cells which leads to the stopping “dilution”, with the help of new cells, of macromolecular defects accumulating at the level of whole cell population. It is concluded that data obtained in testing on the yeast CA model of various factors for their geropromoter or geroprotector activity can be with high reliability used for understanding mechanisms of human aging and longevity.
About the Author
A. N. Khokhlov
Evolutionary Cytogerontology Sector, School of Biology, M.V. Lomonosov Moscow State University, Leninskiye gory 1-12, Moscow, 119234, Russia
Russian Federation
Russian Federation
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For citations:
Khokhlov A.N. WHICH AGING IN YEAST IS “TRUE”? Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2016;(1):14-16. (In Russ.)
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