EFFECTS OF CHRONICAL INJECTIONS OF CLEBOPRIDE IN LOW DOSES ON BEHAVIOR REACTIONS OF WHITE RATS
https://doi.org/10.1234/XXXX-XXXX-2013-4-3-8
Abstract
Effects of the selective D2-receptors antagonist clebopride on behavior of adult males rats was studied in such tests as sucrose consumption, “open field”, “elevated plus maze” and “complex maze” with a food reinforcement. The drug was injected in small doses (0,2 and 0,4 mg/kg) chronically within two weeks. It was shown that clebopride may have an influence on emotionally-motivational state of experimental animals, on the one hand, causing depressive-like changes, and on the other — improve learning ability and research behavior. A variety of consequences of D2-antagonist action is caused, apparently, by a competition of it’s post- and presynaptic effects.
About the Authors
A. V. MalyshevRussian Federation
A. M. Zakharov
Russian Federation
K. Yu. Sarkisova
Институт высшей нервной деятельности и нейрофизиологии РАН, лаборатория функциональной биохимии нервной системы, г. Москва
Russian Federation
Russian Federation
V. A. Dubynin
Russian Federation
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Review
For citations:
Malyshev A.V., Zakharov A.M., Sarkisova K.Yu., Dubynin V.A. EFFECTS OF CHRONICAL INJECTIONS OF CLEBOPRIDE IN LOW DOSES ON BEHAVIOR REACTIONS OF WHITE RATS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2013;(4):3-8. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2013-4-3-8
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