TRANSGENERATIONAL INHERITANCE OF LONGEVITY: THEORETICAL FRAMEWORK AND EMPIRICAL EVIDENCE
Abstract
A number of experimental and epidemiological investigations have provided evidence that the health status and aging rate may largely depend on the conditions in which an organism’s early development takes place. In several recent studies, data are obtained suggesting that the effects of stresses in an early development can be inherited transgenerationally, causing changes of various characteristics in subsequent generations. There have been shown that epigenetic regulation of genetic expression, including DNA methylation, histone and microRNAs modifications, can play a key role in transgenerational inheritance. Until now, it has been generally accepted that the complete erasure of epigenetic marks takes place during the gametogenesis and early embryogenesis. In recent years, however, data were provided demonstrating that epigenetic marks could be not erased completely during these periods of early ontogenesis and some of them can likely be transmitted to the descendants of several generations affecting their phenotype. In this review, the data of epidemiological and experimental studies are provided showing the possibility of inheritance of life expectancy and associated with longevity traits in several generations.
About the Authors
O. G. Zabuga
Chebotarev Institute of Gerontology, Ukrainian National
Academy of Medical Sciences, Kiev
Ukraine
Laboratory of epigenetics
Ukraine
Laboratory of epigenetics
A. M. Vaiserman
Chebotarev Institute of Gerontology, Ukrainian National
Academy of Medical Sciences, Kiev
Ukraine
Laboratory of epigenetics
Ukraine
Laboratory of epigenetics
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Review
For citations:
Zabuga O.G., Vaiserman A.M. TRANSGENERATIONAL INHERITANCE OF LONGEVITY: THEORETICAL FRAMEWORK AND EMPIRICAL EVIDENCE. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2016;(4):19-27. (In Russ.)
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