INFLUENCE OF ORIGINAL STRUCTURAL ANALOGUE AVP(6-9), Ac-D-SPRG, ON EXPLORATORY ACTIVITY AND LEVEL OF ANXIETY OF WHITE RATS
https://doi.org/10.1234/XXXX-XXXX-2012-1-3-7
Abstract
The influence of synthetic structural analogue of arginineasopressin (AVP) Ac-D-SPRG on orientation and exploratory activity and level of anxiety of white rats was studied. The c-D-SPRG was injected nasally in doses of 0,01; 0,1; 1,0 and 10,0 mg/kg in volume of 1 ml per 10 g of body weight 5 min before the testing. The analogue caused depression of orientation and exploratory activity (OEA) and increase of anxiety level in animals. The contradictory literature data give no opportunity to conclude unambiguously on mechanisms underlying bases of regulation of anxiety level and OEA from AVP but nevertheless confirm the participation of this hormone in given process.
About the Authors
A. S. BelyakovaRussian Federation
O. G. Voskresenskaya
Russian Federation
A. A. Kamensky
Russian Federation
V. P. Golubovich
Институт биоорганической химии НАН Беларуси, Республика Беларусь.
Russian Federation
Russian Federation
References
1. Herbert E. Discovery of pro-opiomelanocortin-cellular polyprotein // Trends in Biochemical Sciences. 1981. Vol. 6. P. 184—188.
2. de Wied D. The influence of the posterior and inter-mediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats // International Journal of Neuropharmacology. 1965. Vol. 4. N 3. P. 157—167.
3. Burbach J.P., Kovacs G.L., de Wied D., van Nispen J.W., Greven H.M. A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide // Science. 1983. Vol. 221. P. 1310—1312.
4. Пономарева Н.С., Воскресенская О.Г., Каменский А.А. Влияние оригинального аналога С-концевого фрагмента вазопрессина на поведение белых крыс // Журн. ВНД. 1998. Т. 48. № 3. С. 471—477.
5. Пономарева Н.С., Воскресенская О.Г., Каменский А.А. Улучшение селективного восприятия и обучения крыс оригинальным аналогом С-концевого фрагмента вазопрессина // Физиол. журн. 1998. Т. 84. № 12. С. 1363—1369.
6. Воскресенская О.Г., Каменский А.А., Голубович В.П. Нейротропная активность синтетического аналога С-концевого фрагмента аргинин-вазопрессина // News of Biomedical Sciences НАН Беларуси. 2004. № 1. С. 72—78.
7. Voskresenskaya O.G., Golubovich V.P., Kamensky A.A. Prenatal administration of analog of AVP(6-9) — Ac-D-MPRG influences on the postpound behavior in white rats // Abstracts of the 21st Congress of the European College of Neuropsychopharmacology, August 20—September 3, 2008. Barcelona, 2008.
8. Никонова А.Б., Макарова Н.В., Титов С.А. Избирательное стимулирование вазопрессином исследовательского поведения у крыс // Журн. ВНД. 1987. Т. 37. № 3. С. 570—572.
9. de Vries G.J., Miller M.A. Anatomy and function of extrahypothalamic vasopressin system in the brain // Prod. Brain Res.1998. Vol. 119. P. 3—20.
10. de Vries G.J., Buijs R.M. The origin of the vasopressinergic and oxitocinergic innervation of the rat brain with special reference to the lateral captum // Brain. Res. 1983. Vol. 273. N 2. P. 307—317.
11. Stemmelin J., Lukovic L., Salome N., Griebel G. Evidence that the lateral septum is involved in the antidepressant-like effects of the vasopressin V1b receptor antagonist, SSR149415 // Neuropsychopharmacology. 2005. Vol. 30. N 1. P. 35—42.
12. Landgraf R. Intracerebrally released vasopressin and oxitocin (measurement, mechanism and behavioural consequences) // J. Neuroendocrinol. 1995. P. 243—253.
13. Everts H.G.J., Koolhaas J.M. Differential modulation of lateral septal vasopressin receptor blockade in spatial-learning, social recognition, and anxiety-related behavior in rats // Behav. Brain Res. 1999. Vol. 99. P. 7—16.
Review
For citations:
Belyakova A.S., Voskresenskaya O.G., Kamensky A.A., Golubovich V.P. INFLUENCE OF ORIGINAL STRUCTURAL ANALOGUE AVP(6-9), Ac-D-SPRG, ON EXPLORATORY ACTIVITY AND LEVEL OF ANXIETY OF WHITE RATS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2012;(1):3-7. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2012-1-3-7
Views:
264
Email this article 