INDUCTION OF TELOMERASE ACTIVITY INCREASE REPROGRAMMING EFFICIENCY OF HUMAN DERMAL FIBROBLASTS
https://doi.org/10.1234/XXXX-XXXX-2012-1-8-14
Abstract
Reprogramming of human cells are a perspective direction of development of cellular biology with distant prospect of use of the given methods for cellular-replacing therapy in clinical practice. One of problems rising on this way is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research we had been offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows to exclude oncogen c-Myc from a used set of genes.
About the Authors
E. B. DashinimaevRussian Federation
I. A. Muchkaeva
Russian Federation
R. R. Faizullin
Russian Federation
Y. Y. Yegorov
Russian Federation
S. S. Akimov
Russian Federation
V. V. Terskikh
Russian Federation
A. V. Vasiliev
Russian Federation
M. P. Kirpichnikov
Russian Federation
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Review
For citations:
Dashinimaev E.B., Muchkaeva I.A., Faizullin R.R., Yegorov Y.Y., Akimov S.S., Terskikh V.V., Vasiliev A.V., Kirpichnikov M.P. INDUCTION OF TELOMERASE ACTIVITY INCREASE REPROGRAMMING EFFICIENCY OF HUMAN DERMAL FIBROBLASTS. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2012;(1):8-14. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2012-1-8-14
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