THE ABILITY OF EXTRACELLULAR PROTEINASES OF MICROMYCETES ASPERGILLUS FLAVIPES, ASPERGILLUS FUMIGATUS AND ASPERGILLUS SYDOWII TO AFFECT PROTEINS OF THE HUMAN HAEMOSTATIC SYSTEM
Abstract
The effect of extracellular proteases of A. flavipes A17, A. fumigatus D1 and A. sydowii 1 to proteins of the human hemostasis system was studied. It was shown that A. fumigatus D1 proteinases are able to hydrolyze wide range of chromogenic peptide substrates of specific human proteinases of the haemostatic system. Proteinases formed by A. flavipes A17 and A. sydowii 1 have a narrow specificity, mainly to thrombin and plasmin substrates. It was first shown that proteinase of A. flavipes A17 is capable to activate protein C and Factor X. Extracellular proteinase produced by A. sydowii 1 has greater fibrinolytic activity as compared with proteinases produced by A. flavipes A17 and A. fumigatus D1.
About the Authors
A. A. Osmolovskiy
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology,
Leninskiye Gory 1–12, Moscow, 119234
A. V. Kurakov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Mycology and Algology, Faculty of Biology,
Leninskiye Gory 1–12, Moscow, 119234
V. G. Kreyer
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology,
Leninskiye Gory 1–12, Moscow, 119234
N. A. Baranova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology,
Leninskiye Gory 1–12, Moscow, 119234
N. S. Egorov
Lomonosov Moscow State University
Russian Federation
Russian Federation
International Biotechnology Center,
Leninskiye Gory 1–12, Moscow, 119234
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For citations:
Osmolovskiy A.A., Kurakov A.V., Kreyer V.G., Baranova N.A., Egorov N.S. THE ABILITY OF EXTRACELLULAR PROTEINASES OF MICROMYCETES ASPERGILLUS FLAVIPES, ASPERGILLUS FUMIGATUS AND ASPERGILLUS SYDOWII TO AFFECT PROTEINS OF THE HUMAN HAEMOSTATIC SYSTEM. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2017;72(1):24-28. (In Russ.)
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