MOLECULAR MODELING OF TETRAMERIZATION DOMAIN OF HUMAN POTASSIUM CHANNEL Kv10.2 IN DIFFERENT OLIGOMERIC STATES
Abstract
Voltage-gated potassium channel Kv10.2 is expressed in the nervous system, but its functions and involvement in the development of human disease remain poorly understood. Mutant forms of Kv10.2 channel were found in patients with epileptic encephalopathy and autistic features. Molecular modeling of the channel spatial structure is an important tool for gaining knowledge about the molecular aspects of the channel functioning and mechanisms responsible for the pathogenesis. In the present work, we performed molecular modeling of the helical fragment of the human Kv10.2 (hEAG2) C-terminal domain in dimeric, trimeric and tetrameric forms. The stability of all forms was confirmed by molecular dynamics simulation. Contacts and interactions, stabilizing the structure, were identified.
About the Authors
V. N. Novoseletsky
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Bioengineering, School of Biology
Leninskiye gory 1-12, Moscow, 119234, Russia
A. D. Volyntseva
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Bioengineering, School of Biology
Leninskiye gory 1-12, Moscow, 119234, Russia
K. V. Shaitan
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Bioengineering, School of Biology
Leninskiye gory 1-12, Moscow, 119234, Russia
O. S. Sokolova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Bioengineering, School of Biology
Leninskiye gory 1-12, Moscow, 119234, Russia
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Review
For citations:
Novoseletsky V.N., Volyntseva A.D., Shaitan K.V., Sokolova O.S. MOLECULAR MODELING OF TETRAMERIZATION DOMAIN OF HUMAN POTASSIUM CHANNEL Kv10.2 IN DIFFERENT OLIGOMERIC STATES. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2017;72(2):82-86. (In Russ.)
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