EFFECTS OF INTRANASAL ADMINISTRATION OF ENDOGENOUS SEROTONERGIC MODULATOR — 5-HYDROXYTRYPTAMINE-MODULIN ON RATS BEHAVIOR
https://doi.org/10.1234/XXXX-XXXX-2012-2-3-8
Abstract
In this article the research results on the effects of 5-ydroxytryptamine-modulin — a little-studied endogenous peptide (Leu-Ser-Ala-Leu), which specifically interacts with 5-HT1B-auto-and heteroreceptors, are presented. The data obtained in the experiments on rats suggest prolonged anxiolytic and antidepressive effect of intranasal 5-HT-modulin administration and give evidence to an essential role of endogenous 5-HT-modulin in the regulation of anxiety and depression.
Keywords
About the Authors
O. I. RudkoRussian Federation
N. I. Sergeyeva
Russian Federation
L. A. Andreyeva
Институт генетики РАН, г. Москва
Russian Federation
Russian Federation
R. A. Danilova
Russian Federation
References
1. Raiteri M., Maura G., Bonanno G., Pittaluga A. Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum // Pharmacol. Exp. Ther. 1986. Vol. 237. N 2. P. 644—648.
2. Maura G., Raiteri M. Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release // Europ. J. Pharmacol. 1986. Vol. 129. N 3. P. 333—337.
3. Grimaldi B., Bonnin A., Fillion M.P., Prudhomme N., Fillion G. 5-Hydroxytryptamine-moduline: a novel endogenous peptide involved in the control of anxiety // Neuroscience. 1999. Vol. 93. N 4. Р. 1223—1225.
4. Sarhan H., Cloёz-Tayarani I., Massot O., Fillion M.P., Fillion G. 5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes // Naunyn-Schmiedebergs Archives of Pharmacology. 1999. Vol. 359. N 1. Р. 40—47.
5. Moret C., Grimaldi B., Massot O., Fillion G. The role and therapeutic potencial of 5-HT-moduline in psychiatry // Semin. Clin. Neuropsychiatry. 2003. Vol. 8. N 2. Р. 137—146.
6. Bolanos-Jimenez F., Manhaes de Castro R.M., Seguin L., Cloez-Tayarani I., Monneret V., Drieu K., Fillion G. Effects of stress on the functional properties of pre- and postsynaptic 5-HT1B receptors in the rat brain // Europ. J. Pharmacol. 1995. Vol. 29. N 2—3. Р. 531—540.
7. Zangen A., Overstreet D.H., Yadid G. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment // J. of Neurochemistry. 1997. Vol. 69. N 6. Р. 2477—2483.
8. Uvnдs-Moberg K., Ahlenius S., Alster P., Hillegaart V. Effects of selective serotonin and dopamine agonists on plasma levels of glucose, insulin and glucagon in the rat // Neuroendocrinology. 1996. Vol. 63. N 3. P. 269—274.
9. Kaiyala K.J., Vincow E.S., Sexton T.J., Neumaier J.F. 5-HT1B receptor mRNA levels in dorsal raphe nucleus: inverse association with anxiety behavior in the elevated plus maze // Pharmacol. Biochem. Behav. 2003. Vol. 75. N 4. P. 769—776.
10. Malleret G., Hen R., Guillou J.L., Segu L., Buhot M.C. 5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze // J. Neurosci. 1999. Vol. 19. N 14. P. 6157—6168.
11. Gingrich J.A., Hen R. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice // Psychopharmacology [Berl]. 2001. Vol. 155. N 1. P. 1—10.
12. Groenink L., van Bogaert M.J., van der Gugten J., Oosting R.S., Olivier B. 5-HT1A receptor and 5-HT1B receptor knockout mice in stress and anxiety paradigms // Behav. Pharmacol. 2003. Vol. 14. N 5—6. P. 369—383.
13. Fillion G., Rousselle J.C., Massot O., Zifa E., Fillion M.P., Prudhomme N. A new peptide, 5-HT-moduline, isolated and purified from mammalian brain specifically interacts with 5-HT1B/1D receptors // Behav. Brain Res. 1996. Vol. 73. N 1—2. Р. 313—317.
14. Massot O., Rousselle J.C., Fillion M.P., Grimaldi B., Cloёz-Tayarani I., Fugelli A., Prudhomme N., Seguin L., Rousseau B., Plantefol M., Hen R., Fillion G. 5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5-hydroxytryptamine1B/1D receptors // Molec. Pharmacol. 1996. Vol. 50. N 4. Р. 752—762.
15. Rousselle J.C., Massot O., Delepierre M., Zifa E., Rousseau B., Fillion G. Isolation and characterization of an endogenous peptide from rat brain interacting specifically with the serotonergic 1B receptor subtypes // J. Biol. Chem. 1996. Vol. 12; 271. N 2. Р. 726—735.
16. Rousselle J.C., Plantefol M., Fillion M.P., Massot O., Pauwels P.J., Fillion G. Specific interaction of 5-HT-moduline with human 5-HT1b as well as 5-HT1d receptors expressed in transfected cultured cells // Naunyn Schmiedebergs Arch Pharmacol. 1998. Vol. 358. N 3. P. 279—286.
17. Grimaldi B., Fillion M.P., Bonnin A., Rousselle J.C., Massot O., Fillion G. Immunocytochemical localization of neurons expressing 5-HT-moduline in the mouse brain // Neuropharmacology. 1997. Vol. 36. N 8. Р. 1079—1087.
18. Clйnet F., Hascoёt M., Fillion G., Galons H., Bourin M. Anxiolytic profile of HG1, a 5-HT-moduline antagonist, in three mouse models of anxiety // Eur. Neuropsychopharmacol. 2004. Vol. 14. N 6. P. 449—456.
19. Seguin L., Seznec J.C., Fillion G. The endogenous cerebral tetrapeptide 5-HT-moduline reduces in vivo the functional activity of central 5-HT1B receptors in the rat // Neurosci Res. 1997. Vol. 27. N 3. P. 277—280.
20. Bentue-Ferrer D., Reymann J.M., Rousselle J.C., Massot O., Bourin M., Allain H., Fillion G. 5-HT-moduline, a 5-HT[1B/1D] receptor endogenous modulator, interacts with dopamine release measured in vivo by microdialysis // Eur. J. Pharmacol. 1998. Vol. 358. N 2. P. 129—137.
21. Shimizu N., Take S., Hori T., Oomura Y. In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: significant enhancement by immobilization stress in rats // Brain Res Bull. 1992. Vol. 28. N 5. P. 727—734.
22. Bonnin A., Grimaldi B., Fillion M.P., Fillion G. Acute stress induces a differential increase of 5-HT-moduline [LSAL] tissue content in various rat brain areas // Brain. Res. 1999. Vol. 17; 825. N 1—2. Р. 152—160.
23. Grimaldi B., Fillion G. 5-HT-moduline controls serotonergic activity: implication in neuroimmune reciprocal regulation mechanisms // Prog. Neurobiol. 2000. Vol. 60. N 1. P. 1—12.
24. Ашмарин И.П., Данилова Р.А., Рудько О.И., Обухова М.Ф., Андреева Л.А., Амельченко Е.М., Зятикова М.Ю., Сергеева Н.И. Исследование поведенческих эффектов нового эндогенного модулятора серотонинергической системы — 5-гидрокситриптаминмодулина // Нейрохимия. 2008. Т. 25. № 1—2. C. 41—48.
25. Pellow S., Chopin P., File S.E., Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat // J. Neurosci. Methods. 1985. Vol. 14. N 3. P. 149—167.
26. Porsolt R.D., Anton G., Blavet N., Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments // Eur. J. Pharmacol. 1978. Vol. 47. N 4. P. 379—391.
27. Ашмарин И.П., Данилова Р.А., Рудько О.И., Обухова М.Ф., Андреева Л.А. Долговременное действие пептидных регуляторов, отложенные и инверсные эффекты холецистокинина-4 и -3 // Мед, акад. журн. 2004. Т. 4. № 1. С. 4—13.
28. Узбеков М.Г. Отставленный эффект тетрапептида tyr-D-ala-gly-phe-NH2 на содержание серотонина в синаптосомах мозга кролика // Бюл. эксперимент. биол. и мед. 1983. Т. 95. № 2. C. 38—40.
29. Герштейн Л.М., Доведова Е.Л., Узбеков М.Г., Голикова Т.Л., Сергутина А.В., Ашмарин И.П. Пролонгированное действие тетрапептидамида на особенности обмена белков и медиаторов в отдельных микроструктурах мозга // Нейрохимия. 1984. Т. 3. C. 236—243.
30. Nagahama H. Acute and long-lasting effects of peripheral injection of caerulein and CCK-8 on the central GABAergic system in mice // Peptides. 1989. Vol. 10. N 6. P. 1247—1251.
31. Harro J., Pold M., Vasar E. Anxiogenic-like action of caerulein, a CCK-8 receptor agonist, in the mouse: influence of acute and subchronic diazepam treatment // Naunyn Schmiedebers Arch. Pharmacol. 1990. Vol. 341. N 1—2. P. 62—67.
32. Ашмарин И.П., Данилова Р.А., Рудько О.И. Исследование пролонгированного действия короткоживущих анксиогенных олигопептидов на крысах // Биомедицина. 2007. № 6. С. 103—110.
33. Ashmarin I.P., Danilova R.A., Rudko O.I., Obukhova M.F., Andreeva L.A., Amelchenko E.M., Zyatikova M.Yu., Sergeeva N.I. Studies of the behavioral effects of a novel tndogenous modulator of the serotonergic system, 5-hydro-xytryptamine-moduline // Neurochemical J. 2008. Vol. 2. N 1—2. P. 33—39.
Review
For citations:
Rudko O.I., Sergeyeva N.I., Andreyeva L.A., Danilova R.A. EFFECTS OF INTRANASAL ADMINISTRATION OF ENDOGENOUS SEROTONERGIC MODULATOR — 5-HYDROXYTRYPTAMINE-MODULIN ON RATS BEHAVIOR. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2012;(2):3-8. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2012-2-3-8
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