THE ROLE OF REACTIVE OXYGEN SPECIES IN INFLAMMATION. MINI-REVIEW
Abstract
Inflammation is a protective response of a multicellular organism to injury. The function of inflammation is to localize and eliminate harmful stimuli, as well as repair (or replace) damaged tissues. There is increasing evidence that reactive oxygen species (ROS) participate in the initiation, progression and resolution of an inflammatory reaction. In this case, ROS act as bactericidal agents and “second messengers” in intracellular signaling. The latter function is performed by post-translational modification of proteins containing redox-sensitive cysteine residues, which are susceptible to oxidation. At the same time, overproduction of ROS can lead to cell and tissue injury and contribute to chronic inflammation underlying many neurodegenerative, cardiovascular and metabolic diseases. In this review, we focus on the role of ROS in critical inflammatory events, including increased vascular permeability and leukocyte extravasation, respiratory burst and phagocytosis, angiogenesis, as well as some events leading to the resolution of inflammation. In addition, we discuss the pathological role of ROS in oxidative stress.
About the Author
M. A . Chelombitko
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Cell Biology and Histology, School of Biology
Leninskiye gory 1–12, Moscow, 119234
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Review
For citations:
Chelombitko M.A. THE ROLE OF REACTIVE OXYGEN SPECIES IN INFLAMMATION. MINI-REVIEW. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2018;73(4):242-246. (In Russ.)
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