Chinese hamster cells in biotechnological and gerontological research
Abstract
A Correction to this article is available
One of the most frequently used model objects in gerontology is yeast, primarily Saccharomyces cerevisiae. A significant amount of data has been accumulated, allowing to believe that in yeast undergoing chronological or “stationary phase” aging, damage is similar to age-related lesions in the cells of multicellular organism. However, studies on yeast, like on any objects, are not without drawbacks; in particular, although yeasts are eukaryotes, in terms of evolution they are far from mammals, which impose a limitation on the studies of non-conservative metabolic pathways in yeast. In some cases, mammalian cells are better for chronological model experiments, for example, Chinese hamster cells. They are actively used in industry for the manufacturing of monoclonal antibodies and recombinant proteins. A significant proportion of these products are produced after cessation of proliferation which initiates chronological aging of the culture. The accumulated data on the features of the function of cell metabolism, growth, culture and the duration of its functional activity are extremely valuable for gerontologists. The exchange of information between these two branches – biotechnological and gerontological – will be beneficial to both parties.
About the Author
G. V. Morgunova
Evolutionary Cytogerontology Sector, School of Biology, Lomonosov Moscow State University
Russian Federation
Leninskiye gory 1–12, Moscow, 119234
Russian Federation
Leninskiye gory 1–12, Moscow, 119234
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Morgunova G.V. Chinese hamster cells in biotechnological and gerontological research. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2020;75(4):237-243. (In Russ.)
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