Effect of Aspergillus fumigatus proteinases on blood plasma proteins
Abstract
Extracellular proteinase of the opportunistic Aspergillus fumigatus D-1 strain (molecular weight ~ 33 kDa, pI 4.6) was isolated. It has been shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity in relation to globular proteins of blood plasma was comparable to fibrinolytic activity. Proteinase did not coagulate human fibrinogen, bovine fibrinogen, and also did not coagulate human and rabbit blood plasma without dilution and twice diluted. A plasminogen activating activity of A. fumigatus D-1 extracellular proteinase was found, which may indicate its ability to indirect fibrinolysis.
About the Authors
A. A. Osmolovskiy
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
Leninskiye gory 1–12, Moscow, 119234
L. Schmidt
Halle-Wittenberg Martin Luther University
Germany
Germany
Faculty of Science I
Universitätsplatz 10, Halle, 06108
A. V. Orekhova
Lomonosov Moscow State University; University of Rome “La Sapienza”
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
Faculty of Pharmacology and Medicine
Leninskiye gory 1–12, Moscow, 119234
Piazzale Aldo Moro 5, Rome, 00185
V. G. Kreyer
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
Leninskiye gory 1–12, Moscow, 119234
N. A. Baranova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
Leninskiye gory 1–12, Moscow, 119234
N. S. Egorov
Lomonosov Moscow State University
Russian Federation
Russian Federation
International Biotechnological Center
Leninskiye gory, 1–12, Moscow, 119234
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Review
For citations:
Osmolovskiy A.A., Schmidt L., Orekhova A.V., Kreyer V.G., Baranova N.A., Egorov N.S. Effect of Aspergillus fumigatus proteinases on blood plasma proteins. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2021;76(2):90-95. (In Russ.)
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