The effect of the Ac-D-MPRG peptide based on the C-terminal fragment of arginine-vasopressin(6-9) on the character of rats of different ages
https://doi.org/10.55959/MSU0137-0952-16-78-2-1
Abstract
In this work, it was found that Ac-D-MPRG, a tetrapeptide synthesized on the basis of the C-terminal fragment of arginine-vasopressin(6-9), upon chronic neonatal administration, affects anxiety and exploratory behavior in rats of three age groups. The most significant effect of the peptide was manifested under more stressful conditions. The rats of the experimental group showed less anxiety. They did less grooming in the Elevated Plus Maze test and increased time in light in the Light-Dark Chamber test. Motor activity changed from passive holding in the prepubertal period to active avoidance in puberty and adulthood. Based on the data obtained, we conclude that the effects of the peptide are manifested only when exposed to a biologically significant stimulus.
Keywords
behavior,
anxiety,
peptide drugs,
arginine-vasopressin analog,
orienting-exploratory reaction,
intranasal administration
Supporting agencies: The work was carried out within the framework of the state task of Lomonosov Moscow State University (No. 121032300071-8), without the support of public or private funds under the agreement on scientific and technical cooperation between the “Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus” and the Biology Faculty.
About the Authors
A. A. Stakhanova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Human and Animal Physiology, Faculty of Biology
1–12 Leninskie gory, Moscow, 119234
O. G. Voskresenskaya
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Human and Animal Physiology, Faculty of Biology
1–12 Leninskie gory, Moscow, 119234
V. P. Golubovich
Applied Biochemistry Laboratory, Institute of Bioorganic Chemistry, National Academy of Science of Belarus
Belarus
Belarus
5/2 Acad. V.F. Kuprevich str., Minsk, 220141
A. A. Kamensky
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Human and Animal Physiology, Faculty of Biology
1–12 Leninskie gory, Moscow, 119234
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Review
For citations:
Stakhanova A.A., Voskresenskaya O.G., Golubovich V.P., Kamensky A.A. The effect of the Ac-D-MPRG peptide based on the C-terminal fragment of arginine-vasopressin(6-9) on the character of rats of different ages. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2023;78(2):102-108. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-78-2-1
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