Investigation of new Aspergillus strains as producers of hemostatically active proteases
https://doi.org/10.55959/MSU0137-0952-16-78-2-7
Abstract
For five species of Aspergillus micromycetes, the diversity of proteolytic activities against human hemostasis proteins was assessed. For every strain, absence of activities similar to hemostatic proteases – thrombin, plasmin, factor Xa, urokinase, and protein C was shown. In addition, no activating activities towards precursors of the named proteases were demonstrated. For A. glaucus, proteases of high activity (58,52 Utyr) and specificity against fibrinogen were found. A. athecius, A. caespitosus и A. wentii, were capable of proteolysis at acidic pH.
About the Authors
A. A. Osmolovsky
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
1–12 Leninskie gory, Moscow, 119234
A. A. Shestakova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
1–12 Leninskie gory, Moscow, 119234
D. Ye. Surkova
Lomonosov Moscow State University;
Economics University
Russian Federation
Russian Federation
Department of Microbiology, Faculty of Biology
Faculty of Biology and Biotechnology, Higher School
1–12 Leninskie gory, Moscow, 119234
20 Myasnitskaya str., Moscow, 101100
R. Lehotská
Slovak Medical University in Bratislava
Slovakia
Slovakia
Department of Microbiology
12 Limbova str., Bratislava, 83303
E. Piecková
Slovak Medical University in Bratislava
Slovakia
Slovakia
Department of Microbiology
12 Limbova str., Bratislava, 83303
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Review
For citations:
Osmolovsky A.A., Shestakova A.A., Surkova D.Ye., Lehotská R., Piecková E. Investigation of new Aspergillus strains as producers of hemostatically active proteases. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2023;78(2):109-114. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-78-2-7
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