Effect of different sweeteners on glycogen content of blood leukocytes and differential leukocyte counts in C57BL/6 mice
https://doi.org/10.55959/MSU0137-0952-16-78-4-6
Abstract
We studied the effect of stevia leaf extract, saccharinate and cyclamate in various dosages on the glycogen content of blood leukocytes in mice, as a necessary substrate for the realization of phagocytosis. An increase of glycogen content was found in all experimental groups which obtained sweeteners at a dosage of 10 mg/g of body weight. The effect of sweeteners on the differential leukocyte counts was found only for mice treated with stevia leaf extract at a dosage of 10 mg/g of body weight. They demonstrated increase of neutrophil-to-lymphocyte ratio. New data expand our understanding of the metabolism of sugar substitutes in the organism and their effect on physiological systems, in particular the hematopoietic and immune systems.
Supporting agencies: The work was supported by state order [FMEN-2022-0003] of Karelian Research Centre RAS (Institute of Biology)
About the Authors
A. G. Kizhina
Institute of Biology of the Karelian Research Centre
Russian Federation
Russian Federation
Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences
M. S. Mashinskas
Petrozavodsk State University
Russian Federation
Russian Federation
E. V. Panova
Institute of Biology of the Karelian Research Centre; Petrozavodsk State University
Russian Federation
Russian Federation
Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences; Petrozavodsk State University
V. V. Ilyukha
Petrozavodsk State University
Russian Federation
Russian Federation
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Supplementary files
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1. Содержание гликогена в нейтрофильных лейкоцитах мышей C57BL/6, получавших различные сахарозаменители. | |
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| Type | Результаты исследования | |
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2. Состав лейкоцитарной формулы мышей C57BL/6, получавших различные сахарозаменители | |
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| Type | Результаты исследования | |
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For citations:
Kizhina A.G., Mashinskas M.S., Panova E.V., Ilyukha V.V. Effect of different sweeteners on glycogen content of blood leukocytes and differential leukocyte counts in C57BL/6 mice. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2023;78(4):273-277. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-78-4-6
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