POLYMORPHISM ESTIMATION OF ALCOHOL BIOTRANSFORMATION GENES ADH1B, ALDH2 AND CYP2E IN THE POPULATIONS OF INDIGENOUS AND NEWLY ARRIVED POPULATION OF SIBERIA
https://doi.org/10.1234/XXXX-XXXX-2011-2-32-34
Abstract
In the article it is studed the polymorphism of the genes ADH1B, ADLH2 and CYP2E1 in the population of Shors, Russians of Siberia and progenis of Russian-Shors marriages. The reliable differences between groups according to the frequency of genotypes and allele are discovered. The article shows the high heterozygosis level of genes ADH1B and ALDH2. The gene distances prove that metis and Shors are very close to each other (d = 0,005) and Russians of Siberia are not similar to the Russians od Cental part of Russia (d = 0,046).
About the Author
N. V. SolopekinRussian Federation
References
1. Lee Sh.-L., Hцц J.-O., Yin Sh.-J. Functionality of allelic variation in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism // Pharmocogenetics. 2004. Vol. 14. N 11. P. 725—732.
2. Марусин А.В., Степанов В.А. и др. Анализ ассоциаций генетического полиморфизма ферментов, метаболизирующих этанол, с риском формирования коронарного атеросклероза // Генетика. 2007. Т. 43. № 3. С. 409—416.
3. Hui Li, Borynskaya S., Kal’ina N. et al. Refined geographic distribution of the oriental ALDH2*504Lys variant // Ann. of Human Genetics. 2009. Vol. 73. P. 335—345.
4. Nei M. Molecular evolutionary genetics. Amsterdam, 1975. 278 p.
5. URL:http://www.alfred.med.yale.edu. 27.05.2010
Review
For citations:
Solopekin N.V. POLYMORPHISM ESTIMATION OF ALCOHOL BIOTRANSFORMATION GENES ADH1B, ALDH2 AND CYP2E IN THE POPULATIONS OF INDIGENOUS AND NEWLY ARRIVED POPULATION OF SIBERIA. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2011;(2):32-34. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2011-2-32-34