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POLYMORPHISM ESTIMATION OF ALCOHOL BIOTRANSFORMATION GENES ADH1B, ALDH2 AND CYP2E IN THE POPULATIONS OF INDIGENOUS AND NEWLY ARRIVED POPULATION OF SIBERIA

https://doi.org/10.1234/XXXX-XXXX-2011-2-32-34

Abstract

In  the  article   it  is studed   the  polymorphism of  the  genes  ADH1B, ADLH2 and  CYP2E1 in the  population of Shors, Russians  of Siberia  and  progenis of Russian-Shors marriages. The  reliable differences  between   groups   according  to  the   frequency  of  genotypes  and   allele   are   discovered. The  article  shows  the  high  heterozygosis level  of  genes  ADH1B and  ALDH2. The  gene  distances prove  that  metis  and  Shors  are  very  close  to  each  other   (d  = 0,005)  and  Russians   of  Siberia  are not  similar  to  the  Russians  od  Cental part  of Russia  (d  = 0,046).

 

About the Author

N. V. Solopekin
кафедра генетики ГОУ ВПО “Кемеровский государственный университет”
Russian Federation


References

1. Lee Sh.-L., Hцц J.-O., Yin Sh.-J. Functionality of allelic variation in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism // Pharmocogenetics. 2004. Vol. 14. N 11. P. 725—732.

2. Марусин А.В., Степанов В.А. и др. Анализ ассоциаций генетического полиморфизма ферментов, метаболизирующих этанол, с риском формирования коронарного атеросклероза // Генетика. 2007. Т. 43. № 3. С. 409—416.

3. Hui Li, Borynskaya S., Kal’ina N. et al. Refined geographic distribution of the oriental ALDH2*504Lys variant // Ann. of Human Genetics. 2009. Vol. 73. P. 335—345.

4. Nei M. Molecular evolutionary genetics. Amsterdam, 1975. 278 p.

5. URL:http://www.alfred.med.yale.edu. 27.05.2010


Review

For citations:


Solopekin N.V. POLYMORPHISM ESTIMATION OF ALCOHOL BIOTRANSFORMATION GENES ADH1B, ALDH2 AND CYP2E IN THE POPULATIONS OF INDIGENOUS AND NEWLY ARRIVED POPULATION OF SIBERIA. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2011;(2):32-34. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2011-2-32-34

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ISSN 0137-0952 (Print)