MODULATION OF NITRIC OXIDE (NO) BIOSYNTHESIS IN LACTOBACILLI
https://doi.org/10.1234/XXXX-XXXX-2011-2-41-43
Abstract
We characterized effects of nitric oxide synthase (NOS) substrate and inhibitors on NO biosynthesis in probiotic bacteria Lactobacillus plantarum 8P-A3. NO-synthase derived origin of de- tected nitric oxide was confirmed by induction of NO production by exogenous L-arginine. None of used inhibitors of three isoforms of mammalian NOSs (L-NAME, L-NIL, nNOS inhibitor I) showed significant inhibitory effect on lactobacillar NO-synthase activity.
About the Authors
D. R. Yarullina
Казанский (Приволжский) федеральный университет, г. Казань
Russian Federation
Russian Federation
O. A. Smolentseva
Казанский (Приволжский) федеральный университет, г. Казань
Russian Federation
Russian Federation
O. N. Ilinskaya
Казанский (Приволжский) федеральный университет, г. Казань
Russian Federation
Russian Federation
References
1. Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition // Biochem. J. 2001. Vol. 357. P. 593—615.
2. Adawi D., Kasravi F.B., Molin G., Jeppsson B. Effect of Lactobacillus supplementation with and without argini- ne on liver damage, bacterial translocation in an acute liver injury model in the rat // Hepatology. 1997. Vol. 25. N 3. P. 642—647.
3. Яруллина Д.Р., Ильинская О.Н., Аганов А.В., Силкин Н.И., Зверев Д.Г. Альтернативные пути образования оксида азота у лактобацилл: обнаружение возможной NO-синтазной активности методом ЭПР // Микробиология. 2006. Т. 75. № 6. С. 731—736.
4. Tsikas D., Boger R.H., Sandmann J., Bode-Boger S.M., Frolich J.C. Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox // FEBS Letters. 2000. Vol. 478. P. 1—3.
5. Choi W.S., Seo D.W., Chang M.S., Han J.W., Hong S.Y., Paik W.K., Lee H.W. Methylesters of L-arginine and N-nit- ro-L-arginine induced nitric oxide synthase in Staphylococcus aureus // Biochem. Biophys. Res. Commun. 1998. Vol. 246. P. 431—435.
6. Wach M.J., Kers J.A., Krasnoff S.B., Loria R., Gibson D.M. Nitric oxide synthase inhibitors and nitric oxide donors modulate the biosynthesis of thaxtomin A, a nitrated phytotoxin produced by Streptomyces spp. // Nitric Oxide. 2005. Vol. 12. P. 46—53.
Review
For citations:
Yarullina D.R., Smolentseva O.A., Ilinskaya O.N. MODULATION OF NITRIC OXIDE (NO) BIOSYNTHESIS IN LACTOBACILLI. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2011;(2):41-43. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2011-2-41-43
Views:
258
Email this article 