НЕПОЛНОЦЕННОЕ ПИТАНИЕ В РАННЕЙ ЖИЗНИ И РИСК РАЗВИТИЯ ДИАБЕТА 2-ГО ТИПА: ТЕОРЕТИЧЕСКИЙ БАЗИС И ЭПИДЕМИОЛОГИЧЕСКИЕ ДОКАЗАТЕЛЬСТВА
Аннотация
Получены многочисленные экспериментальные и эпидемиологические доказательства того, что недостаточное питание во время раннего развития может влиять на риск развития метаболических патологий во взрослой жизни, включая сахарный диабет 2-го типа (СД2Т). Большая часть эпидемиологических доказательств подобной связи получена в квазиэкспериментальных исследованиях (“естественных экспериментах”), реализованных в популяциях разных стран мира. В этих исследованиях показано, что воздействие голода в течение пренатального и/или раннего постнатального развития связано с повышенным риском развития СД2Т во взрослой жизни. В качестве основного механизма, за счёт которого реализуется связь между воздействием голода в ранней жизни и повышенным риском СД2Т у взрослых людей, рассматривается эпигенетическая регуляция активности генов. Предполагается, что пренатальное воздействие голода может вызывать устойчивые эпигенетические изменения, которые имеют адаптивное значение на протяжении раннего постнатального развития, но предрасполагают к метаболическим нарушениям, включая СД2Т, в дальнейшей жизни. В представленном обзоре обобщены и обсуждены данные квазиэкспериментальных исследований, свидетельствующие о возможности раннего программирования риска СД2Т.
Об авторах
О. Г. Забуга
ГУ “Институт геронтологии им. Д.Ф. Чеботарёва” НАМНУ
Украина
Украина
Украина, 04114, г. Киев, ул. Вышгородская, д. 67
канд. биол. наук, мл. науч. сотр. лаборатории эпигенетики ГУ “Институт геронтологии им. Д.Ф. Чеботарева НАМН Украины”, Киев. Тел.: + 38 (044) 431-05-58
А. М. Вайсерман
ГУ “Институт геронтологии им. Д.Ф. Чеботарёва” НАМНУ
Украина
Украина
Украина, 04114, г. Киев, ул. Вышгородская, д. 67
докт. мед. наук, зав. лабораторией эпигенетики ГУ “Институт геронтологии им. Д.Ф. Чеботарева НАМН Украины”, Киев. Тел.: + 38 (044) 431-05-58
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Рецензия
Для цитирования:
Забуга О.Г., Вайсерман А.М. НЕПОЛНОЦЕННОЕ ПИТАНИЕ В РАННЕЙ ЖИЗНИ И РИСК РАЗВИТИЯ ДИАБЕТА 2-ГО ТИПА: ТЕОРЕТИЧЕСКИЙ БАЗИС И ЭПИДЕМИОЛОГИЧЕСКИЕ ДОКАЗАТЕЛЬСТВА. Вестник Московского университета. Серия 16. Биология. 2017;72(2):47-57.
For citation:
Zabuga O.G., Vaiserman A.M. MALNUTRITION IN EARLY LIFE AND RISK OF TYPE 2 DIABETES: THEORETICAL BASIS AND EPIDEMIOLOGICAL EVIDENCE. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2017;72(2):47-57. (In Russ.)
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