The effect of a single heating treatment on laboratory mice behaviour, adult neurogenesis and the expression of heatshock protein HSP70

Male hybrid mice (F1 CBA x C57BL/6J) were kept for 1.5 h at the temperature 39,5°С. In cognitive tests (extrapolation and puzzle-box elementary logic task solution) mice of experimental groups (after being kept in elevated temperature environment) solved the tasks more quickly and more successfully, while their activity the «small open field» (in which no stress-inducing stimuli were present) and in Porsolt test (unescapable swimming) was higher than in control mice. tests they were also more active. In separate experiments the temporary impairment in the adult neurogenesis (the decrease of new cells numbers detected immunо-histochemically by the marker Ki67) after elevated temperature exposure was demonstrated in both subgranular area of dentate fascia and in subventricular proliferative zone of the forebrain. The heating treatment was accompanied by the increase of HSP70 expression at the time point 3 h after the treatment but which was not different from the controls after 24 h.

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