Structural study of the Candida auris ribosome
https://doi.org/10.55959/MSU0137-0952-16-78-3S-8
Abstract
Candida auris is a pathogenic fungus that causes infections in people with weakened immune systems. It is resistant to antimicrobial drugs, which complicates treatment. C. auris poses a serious threat to public health, as it has a high resistance and contagiousness. The ribosome plays an important role in the survival and development of this infection, and the search for inhibitors of the C. auris ribosome is of great importance. We used cryoelectron microscopy and single particle analysis to obtain the three-dimensional structure of the C. auris ribosome. We describe the architecture of the ribosome subunits and their interactions, providing valuable information for the development of novel anti-fungals against C. auris.
Keywords
Supporting agencies: The research was funded by Russian Science Foundation, project number 20-64-47041.
About the Authors
A. A. Atamas
Center for Research on Molecular Mechanisms of Aging and Age-Related Diseases, Moscow University of Physics and Technology
Russian Federation
Russian Federation
9 Institutskiy per., Dolgoprudny, 141701, Moscow region
А. Гуськов
Center for Research on Molecular Mechanisms of Aging and Age-Related Diseases, Moscow University of Physics and Technology
Russian Federation
Russian Federation
9 Institutskiy per., Dolgoprudny, 141701, Moscow region
А. Рогачев
Center for Research on Molecular Mechanisms of Aging and Age-Related Diseases, Moscow University of Physics and Technology
Russian Federation
Russian Federation
9 Institutskiy per., Dolgoprudny, 141701, Moscow region
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Review
For citations:
Atamas A.A., , Structural study of the Candida auris ribosome. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2023;78(3S):47-50. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-78-3S-8
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