Structural features of carotenoid-binding proteins
https://doi.org/10.55959/MSU0137-0952-16-80-3S-13
Abstract
Carotenoid-protein complexes play a crucial role in photosynthesis, photoreception, protection against oxidative stress, metabolism, and pigmentation. This study conducts a detailed analysis of structural data with atomic resolution for carotenoid-containing proteins. The research examines molecular features of carotenoid-binding regions and structural characteristics of bound carotenoids. The findings reveal general principles of the protein-carotenoid interface organization, essential for developing new approaches to targeted modification. Additionally, a machine learning model is created to predict carotenoid-binding activity based on the primary protein structure.
Supporting agencies: This work was supported by the Russian Science Foundation (project no. 25-74-20001).
About the Authors
M. M. Surkov
Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–24 Leninskie gory, 119234, Moscow
A. Yu. Litovets
Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–24 Leninskie gory, 119234, Moscow
A. A. Mamchur
Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–24 Leninskie gory, 119234, Moscow
T. B. Stanishneva-Konovalova
Department of Bioengineering, Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–73 Leninskie gory, 119234, Moscow
I. A. Yaroshevich
Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Russian Federation
1–24 Leninskie gory, 119234, Moscow
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Surkov M.M., Litovets A.Yu., Mamchur A.A., Stanishneva-Konovalova T.B., Yaroshevich I.A. Structural features of carotenoid-binding proteins. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2025;80(3S):87–95. (In Russ.) https://doi.org/10.55959/MSU0137-0952-16-80-3S-13
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