MOLECULAR MECHANISMS OF TRANSCRIPTION THROUGH CHROMATIN BY RNA POLYMERASE III

The nucleosome forms the so-called “nucleosome barrier”, which presents a serious obstacle to the transcription machinery. We consider the study of formation and overcoming of the “nucleosomal barrier” by different RNA polymerases. It is shown that similar mechanisms are used by very different polymerases for transcription through chromatin. We discuss the data showing a high similarity between the mechanisms of transcription through chromatin and ATP-dependent chromatin remodeling. A model of transcription through the nucleosome is proposed.

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