Sex-specific behavioral characteristics of rats with fetal valproate syndrome
Abstract
Both male and female Wistar rats with experimental model of autism spectrum disorders induced by prenatal administration of valproate sodium at a dose of 500 mg/kg have behavioral abnormalities similar for people with these disorders, including abnormalities of social interaction, locomotor, orientation and exploratory behaviour, coordination of movement, spatial exploration behavior and hyperactivity in previously explored “familiar” environments. The severity of behavioral abnormalities in rats with fetal valproate syndrome exhibits sex differences, which must be taken into account when conducting experimental studies on this model.
About the Authors
I. G. Kapitsa
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Laboratory of Psychopharmacology
ul. Baltiyskaya 8, Moscow, 125315
Е. А. Ivanova
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Laboratory of Psychopharmacology
ul. Baltiyskaya 8, Moscow, 125315
Т. А. Voronina
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Laboratory of Psychopharmacology
ul. Baltiyskaya 8, Moscow, 125315
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Review
For citations:
Kapitsa I.G., Ivanova Е.А., Voronina Т.А. Sex-specific behavioral characteristics of rats with fetal valproate syndrome. Vestnik Moskovskogo universiteta. Seriya 16. Biologiya. 2020;75(2):107-114. (In Russ.)
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